A green synthesis of 1,7-dihydrodipyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one derivatives from deamination cyclization reactions in aqueous medium

被引：6

作者：

Xu, Hui ^{[1
]}

Li, Lei ^{[1
]}

Wang, Zhansheng ^{[1
]}

Xi, Junhua ^{[1
]}

Rong, Liangce ^{[1
]}

机构：

[1] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2018年 / 44卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Pyrazolo[3,4-b:4 ',3 '-e]pyridine; Green synthesis; Deamination reaction; Aqueous medium; 3-Amino-1-phenyl-1H-pyrazol-5(4H)-one; BIOLOGICAL EVALUATION; PYRAZOLOPYRIDINE DERIVATIVES; ONE-POT; WATER; EFFICIENT; INHIBITORS; ANTAGONISTS; ACTIVATION; SYSTEMS; FACILE;

D O I：

10.1007/s11164-018-3302-7

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Efficient and green reactions of different aromatic aldehydes, 3-amino-1-phenyl-1H-pyrazol-5(4H)-one, and substituted 3-aminopyrazoles for the synthesis of pyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one derivatives have been reported through deamination cyclization reactions. This is a new route for the generation of pyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one compounds. According to the reported literature, these kinds of compounds have important optical properties, and have potential application prospects. Other advantages of this process are simple operation, easy separation, and a wide range of substrates. Best of all, this method possesses an environmentally benign procedure.

引用

收藏

页码：3211 / 3226

页数：16

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