A green synthesis of 1,7-dihydrodipyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one derivatives from deamination cyclization reactions in aqueous medium

Efficient and green reactions of different aromatic aldehydes, 3-amino-1-phenyl-1H-pyrazol-5(4H)-one, and substituted 3-aminopyrazoles for the synthesis of pyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one derivatives have been reported through deamination cyclization reactions. This is a new route for the generation of pyrazolo[3,4-b:4',3'-e]pyridin-3(2H)-one compounds. According to the reported literature, these kinds of compounds have important optical properties, and have potential application prospects. Other advantages of this process are simple operation, easy separation, and a wide range of substrates. Best of all, this method possesses an environmentally benign procedure.