Ruthenium-Catalyzed ortho-Alkenylation of Phenylphosphine Oxides through Regio- and Stereoselective Alkyne Insertion into C-H Bonds

被引：72

作者：

Itoh, Masaki ^{[1
]}

Hashimoto, Yuto ^{[1
]}

Hirano, Koji ^{[1
]}

Satoh, Tetsuya ^{[1
,2
]}

Miura, Masahiro ^{[1
]}

机构：

[1] Osaka Univ, Fac Engn, Dept Appl Chem, Suita, Osaka 5650871, Japan

[2] JST, ACT C, Kawaguchi, Saitama 3320012, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2013年 / 78卷 / 16期

关键词：

CHIRAL PHOSPHINE OXIDE; ALDOL REACTION; ARYL HALIDES; FUNCTIONALIZATION; ACTIVATION; REDUCTION; ARENES; HYDROARYLATION; ALLYLATION; COMPLEXES;

D O I：

10.1021/jo401393b

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct ortho-substitution took place efficiently upon treatment of tri-, di-, and monoarylphosphine oxides with internal alkynes in the presence of a ruthenium catalyst to produce (o-alkenylphenyl)phosphine oxides regio- and stereo-selectively. Chemoselective reduction of a product gave the corresponding (o-alkenylphenyl)phosphine, which may be useful as a ligand for transition metals.

引用

页码：8098 / 8104

页数：7

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