Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells

被引：11
作者：
Bin, Hee-Shin [1 ,2 ]
Jeong, Jae-Hyun [1 ]
Choi, Ung-Kyu [1 ]
机构：
[1] Korea Natl Univ Transportat, Dept Food Sci & Technol, Jeungpyeong 368701, Chungbuk, South Korea
[2] Daewon Food Serv Co, Jincheon 365823, Chungbuk, South Korea
来源：
FOOD SCIENCE AND BIOTECHNOLOGY | 2013年 / 22卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
chlorogenic acid; human adipose tissue-derived mesenchymal stem cell; osteogenesis; alkaline phosphatase; MARROW STROMAL CELLS; ACTIVATED-RECEPTOR-GAMMA; OSTEOGENIC DIFFERENTIATION; IN-VITRO; BONE; ADIPOGENESIS; EXPRESSION; CULTURES;
D O I：
10.1007/s10068-013-0055-3
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Chlorogenic acid (CGA) is one of the most abundant polyphenols in the human diet and has various biological properties such as antimicrobial and antioxidant activities. Although the biophysiological effects of CGA are well studied, its effect on stem cell differentiation has not been observed until recently. In this study, it was demonstrated that CGA promotes osteogenesis in human adipose tissue-derived mesenchymal stem cells (hAMSCs), as indicated by increased mineralization. The mRNA levels of alkaline phosphatase and runt-related transcription factor 2 increased significantly following treatment with 30 mu M CGA. These results suggest a novel effect of CGA on osteogenic differentiation in hAMSCs and the possibility that CGA might affect the differentiation of other types of stem cells.
引用
收藏
页码：107 / 112
页数：6
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