Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells

被引：11
|
作者：
Bin, Hee-Shin [1 ,2 ]
Jeong, Jae-Hyun [1 ]
Choi, Ung-Kyu [1 ]
机构：
[1] Korea Natl Univ Transportat, Dept Food Sci & Technol, Jeungpyeong 368701, Chungbuk, South Korea
[2] Daewon Food Serv Co, Jincheon 365823, Chungbuk, South Korea
来源：
FOOD SCIENCE AND BIOTECHNOLOGY | 2013年 / 22卷 / 01期
基金：
新加坡国家研究基金会;
关键词：
chlorogenic acid; human adipose tissue-derived mesenchymal stem cell; osteogenesis; alkaline phosphatase; MARROW STROMAL CELLS; ACTIVATED-RECEPTOR-GAMMA; OSTEOGENIC DIFFERENTIATION; IN-VITRO; BONE; ADIPOGENESIS; EXPRESSION; CULTURES;
D O I：
10.1007/s10068-013-0055-3
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Chlorogenic acid (CGA) is one of the most abundant polyphenols in the human diet and has various biological properties such as antimicrobial and antioxidant activities. Although the biophysiological effects of CGA are well studied, its effect on stem cell differentiation has not been observed until recently. In this study, it was demonstrated that CGA promotes osteogenesis in human adipose tissue-derived mesenchymal stem cells (hAMSCs), as indicated by increased mineralization. The mRNA levels of alkaline phosphatase and runt-related transcription factor 2 increased significantly following treatment with 30 mu M CGA. These results suggest a novel effect of CGA on osteogenic differentiation in hAMSCs and the possibility that CGA might affect the differentiation of other types of stem cells.
引用
收藏
页码：107 / 112
页数：6
相关论文
共 50 条
  • [1] Chlorogenic acid promotes osteoblastogenesis in human adipose tissue-derived mesenchymal stem cells
    Hee-Shin Bin
    Jae-Hyun Jeong
    Ung-Kyu Choi
    Food Science and Biotechnology, 2013, 22 : 107 - 112
  • [2] Myricetin inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells
    Bin, Hee-Shin
    Choi, Ung-Kyu
    FOOD SCIENCE AND BIOTECHNOLOGY, 2012, 21 (05) : 1391 - 1396
  • [3] Myricetin inhibits adipogenesis in human adipose tissue-derived mesenchymal stem cells
    Hee-Shin Bin
    Ung-Kyu Choi
    Food Science and Biotechnology, 2012, 21 : 1391 - 1396
  • [4] Schizophyllan promotes osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro
    Hemati, Saideh
    Hatamian-Zarmi, Ashrafalsadat
    Halabian, Raheleh
    Ghiasi, Mohsen
    Salimi, Ali
    MOLECULAR BIOLOGY REPORTS, 2023, 50 (12) : 10037 - 10045
  • [5] Schizophyllan promotes osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells in vitro
    Saideh Hemati
    Ashrafalsadat Hatamian-Zarmi
    Raheleh Halabian
    Mohsen Ghiasi
    Ali Salimi
    Molecular Biology Reports, 2023, 50 : 10037 - 10045
  • [6] Differentiation of Adipose Tissue-Derived Mesenchymal Stem Cells Into Cardiomyocytes
    Carvalho, Pablo Herthel
    Falci Daibert, Ana Paula
    Monteiro, Betania Souza
    Okano, Barbara Silva
    Carvalho, Juliana Lott
    Queiroz da Cunha, Daise Nunes
    Campos Favarato, Lukiya Silva
    Pereira, Vanessa Guedes
    Franklin Augusto, Luis Eugenio
    Del Carlo, Ricardo Junqueira
    ARQUIVOS BRASILEIROS DE CARDIOLOGIA, 2013, 100 (01) : 82 - 89
  • [7] Adipose tissue-derived mesenchymal stem cells for breast tissue regeneration
    Banani, Mohammed Ali
    Rahmatullah, Mohammed
    Farhan, Nawras
    Hancox, Zoe
    Yousaf, Safiyya
    Arabpour, Zohreh
    Moghaddam, Zoha Salehi
    Mozafari, Masoud
    Sefat, Farshid
    REGENERATIVE MEDICINE, 2021, 16 (01) : 47 - 70
  • [8] Oxidative Stress Response in Adipose Tissue-Derived Mesenchymal Stem/Stromal Cells
    Waheed, Tawakalitu Okikiola
    Hahn, Olga
    Sridharan, Kaarthik
    Morke, Caroline
    Kamp, Gunter
    Peters, Kirsten
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (21)
  • [9] Differential Effects of Vascular Endothelial Growth Factor on Bone Regeneration of Human Adipose Tissue-Derived Mesenchymal Stem Cells and Bone Marrow Mesenchymal Stem Cells
    Lim, Jiwon
    Noh, Hey Jeong
    Yang, Jungho
    You, Changkook
    Yun, Hui-Suk
    Shin, Hong-In
    Kim, Shin-Yoon
    Park, Eui Kyun
    TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2013, 10 : 19 - 27
  • [10] Wedelolactone inhibits adipogenesis through the ERK pathway in human adipose tissue-derived mesenchymal stem cells
    Lim, Seyoung
    Jang, Hyun-Jun
    Park, Eun Hee
    Kim, Jung Kuk
    Kim, Jung-Min
    Kim, Eung-Kyun
    Yea, Kyungmoo
    Kim, Yun-Hee
    Lee-Kwon, Whaseon
    Ryu, Sung Ho
    Suh, Pann-Ghill
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2012, 113 (11) : 3436 - 3445
12345