A balanced view of calcium and phosphate homeostasis in chronic kidney disease

被引:22
作者
Evenepoel, Pieter [1 ]
Wolf, Myles [2 ]
机构
[1] Univ Hosp Leuven, Div Nephrol, Dept Immunol & Microbiol, B-3000 Louvain, Belgium
[2] Univ Miami, Miller Sch Med, Div Nephrol & Hypertens, Dept Med, Miami, FL 33136 USA
关键词
METABOLISM; OSTEOPOROSIS; PHOSPHORUS; ABSORPTION; TERM;
D O I
10.1038/ki.2013.21
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 ; 100201 ;
摘要
The association of abnormalities of calcium and phosphate homeostasis with adverse clinical outcomes in chronic kidney disease (CKD) has generated interest in developing therapeutic strategies to target mineral metabolism early in the course of CKD. Hill et al. present results from a classic balance study of CKD stage 3-4 patients that challenge existing paradigms and suggest a need to rethink our understanding of calcium and phosphate homeostasis in CKD.
引用
收藏
页码:789 / 791
页数:4
相关论文
共 11 条
[1]  
[Anonymous], 2001, HUM VIT MIN REQ REP
[2]   Mineral metabolism parameters throughout chronic kidney disease stages 1-5 -: achievement of K/DOQI target ranges [J].
Craver, Lourdes ;
Paz Marco, Maria ;
Martinez, Isabel ;
Rue, Montserrat ;
Borras, Merce ;
Luisa Martin, Maria ;
Sarro, Felipe ;
Manuel Valdivielso, Jose ;
Fernandez, Elvira .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2007, 22 (04) :1171-1176
[3]   1,25-DIHYDROXYVITAMIN-D3 - SHORT-TERM AND LONG-TERM EFFECTS ON BONE AND CALCIUM-METABOLISM IN PATIENTS WITH POST-MENOPAUSAL OSTEOPOROSIS [J].
GALLAGHER, JC ;
JERPBAK, CM ;
JEE, WSS ;
JOHNSON, KA ;
DELUCA, HF ;
RIGGS, BL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (10) :3325-3329
[4]   CALCIUM METABOLISM IN OSTEOPOROSIS - ACUTE AND LONG-TERM RESPONSES TO INCREASED CALCIUM INTAKE [J].
HARRISON, M ;
FRASER, R ;
MULLAN, B .
LANCET, 1961, 1 (718) :1015-&
[5]   Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease [J].
Hasegawa, Hisashi ;
Nagano, Nobuo ;
Urakawa, Itaru ;
Yamazaki, Yuji ;
Iijima, Kousuke ;
Fujita, Toshiro ;
Yamashita, Takeyoshi ;
Fukumoto, Seiji ;
Shimada, Takashi .
KIDNEY INTERNATIONAL, 2010, 78 (10) :975-980
[6]   Oral calcium carbonate affects calcium but not phosphorus balance in stage 3-4 chronic kidney disease [J].
Hill, Kathleen M. ;
Martin, Berdine R. ;
Wastney, Meryl E. ;
McCabe, George P. ;
Moe, Sharon M. ;
Weaver, Connie M. ;
Peacock, Munro .
KIDNEY INTERNATIONAL, 2013, 83 (05) :959-966
[7]   Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease [J].
Isakova, Tamara ;
Wahl, Patricia ;
Vargas, Gabriela S. ;
Gutierrez, Orlando M. ;
Scialla, Julia ;
Xie, Huiliang ;
Appleby, Dina ;
Nessel, Lisa ;
Bellovich, Keith ;
Chen, Jing ;
Hamm, Lee ;
Gadegbeku, Crystal ;
Horwitz, Edward ;
Townsend, Raymond R. ;
Anderson, Cheryl A. M. ;
Lash, James P. ;
Hsu, Chi-yuan ;
Leonard, Mary B. ;
Wolf, Myles .
KIDNEY INTERNATIONAL, 2011, 79 (12) :1370-1378
[8]   A blueprint for randomized trials targeting phosphorus metabolism in chronic kidney disease [J].
Isakova, Tamara ;
Gutierrez, Orlando M. ;
Wolf, Myles .
KIDNEY INTERNATIONAL, 2009, 76 (07) :705-716
[9]   THE ABSORPTION OF DIETARY PHOSPHORUS AND CALCIUM IN HEMODIALYSIS-PATIENTS [J].
RAMIREZ, JA ;
EMMETT, M ;
WHITE, MG ;
FATHI, N ;
ANA, CAS ;
MORAWSKI, SG ;
FORDTRAN, JS .
KIDNEY INTERNATIONAL, 1986, 30 (05) :753-759
[10]   Calcium balance in normal individuals and in patients with chronic kidney disease on low- and high-calcium diets [J].
Spiegel, David M. ;
Brady, Kate .
KIDNEY INTERNATIONAL, 2012, 81 (11) :1116-1122