Synthesis, DFT and Antimicrobial Studies of 5,6,7,8- Tetrachloro Phthalazin-1-ol and 2,3-Benzoxazin-1(2H)-one Derivatives

被引：4
作者：
Rizk, Sameh A. [1 ]
Youssef, Mohamed Fathy [2 ]
Mubarak, Ahmed M. [2 ]
机构：
[1] Ain Shams Univ, Fac Sci, Chem Dept, Cairo, Egypt
[2] Suez Canal Univ, Fac Sci, Chem Dept, Ismailia, Egypt
来源：
EGYPTIAN JOURNAL OF CHEMISTRY | 2020年 / 63卷 / 05期
关键词：
Phthalazin-l-ol; 2,3-Benzoxazin-1-one; 2-Methyl-phthalazinone; DFT Antimicrobial reagents; ALDOSE REDUCTASE INHIBITORS; REGIOSELECTIVE REACTION; ACID; POTENT; HYDRALAZINE; BUDRALAZINE; DESIGN; SERIES; AGENTS;
D O I：
10.21602/ejchem.2019.16936.2036
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
2-AROYLBENZOIC acidwas allowed to react with hydrazine hydrate, hydroxylamine and methylhydrazine to afford the corresponding 5,6,7,8-tetrachloro-4-aryl-phthalazin-1-one. The antimicrobial effect of the phthalazin-1-one in the water of the swimming pool and river can be discussed. DFT based on quantum chemical computational of the new compounds were synthesized with the objective of studying their antimicrobial activity. The newly synthesized compounds were characterized on the basis of theirspectral (H-1-NMR, Mass spectrum, IR and Elementary analysis
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页码：1767 / 1777
页数：11
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