Mechanisms and Mediators That Drive Arthritis Pain

被引：57

作者：

Krustev, Eugene ^{[1
]}

Rioux, Danielle ^{[1
]}

McDougall, Jason J. ^{[1
,2
]}

机构：

[1] Dalhousie Univ, Dept Pharmacol, Halifax, NS B3H 4R2, Canada

[2] Dalhousie Univ, Dept Anaesthesia Pain Management & Perioperat Med, Halifax, NS B3H 4R2, Canada

来源：

CURRENT OSTEOPOROSIS REPORTS | 2015年 / 13卷 / 04期

关键词：

Arthritis; Pain; Inflammation; Neuropathic pain; Cytokines; Neurogenic inflammation; Proteinases; Cannabinoids; Voltage-gated ion channels; Nerve growth factor; NERVE GROWTH-FACTOR; ROOT GANGLION NEURONS; CALCIUM-CHANNEL SUBUNIT; INTESTINAL-PEPTIDE VIP; RAT SENSORY NEURONS; KNEE-JOINT; NEUROPATHIC PAIN; DOUBLE-BLIND; SUBSTANCE-P; SOMATOSTATIN RECEPTORS;

D O I：

10.1007/s11914-015-0275-y

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

There are over 100 different types of arthritis and each can differ greatly in their aetiology and pathophysiology; however, one characteristic that is common to all arthritic conditions is joint pain. Musculoskeletal pain is the leading cause of disability in the world, and the number one reason arthritis patients visit their primary care physician. Despite the prevalence and burden of arthritis pain, current analgesics lack sufficient efficacy and are plagued by multiple adverse side effects. In this review, we outline the current landscape of research concerning joint pain, drawing from both preclinical and clinical studies. Specifically, this review is a discussion of the different neurophysiological processes that occur during joint disease and how inflammatory and neuropathic aspects contribute to the development of arthritis pain.

引用

页码：216 / 224

页数：9

共 95 条

[1] Anti-Citrullinated Peptide Antibody Assays and Their Role in the Diagnosis of Rheumatoid Arthritis [J].

Aggarwal, Rohit ;

Liao, Katherine ;

Nair, Raj ;

Ringold, Sarah ;

Costenbader, Karen H. .

ARTHRITIS & RHEUMATISM-ARTHRITIS CARE & RESEARCH, 2009, 61 (11) :1472-1483

[2] PERIPHERAL ADMINISTRATION OF NERVE GROWTH-FACTOR IN THE ADULT-RAT PRODUCES A THERMAL HYPERALGESIA THAT REQUIRES THE PRESENCE OF SYMPATHETIC POSTGANGLIONIC NEURONS [J].

ANDREEV, NY ;

DIMITRIEVA, N ;

KOLTZENBURG, M ;

MCMAHON, SB .

PAIN, 1995, 63 (01) :109-115

[3] Efficacy and safety of tanezumab added on to diclofenac sustained release in patients with knee or hip osteoarthritis: a double-blind, placebo-controlled, parallel-group, multicentre phase III randomised clinical trial [J].

Balanescu, Andra Rodica ;

Feist, Eugen ;

Wolfram, Gernot ;

Davignon, Isabelle ;

Smith, Michael D. ;

Brown, Mark T. ;

West, Christine R. .

ANNALS OF THE RHEUMATIC DISEASES, 2014, 73 (09) :1665-1672

[4] The expression and localization of somatostatin receptors in dorsal root ganglion neurons of normal and monoarthritic rats [J].

Bär, KJ ;

Schurigt, U ;

Scholze, A ;

Von Banchet, GS ;

Stopfel, N ;

Bräuer, R ;

Halbhuber, KJ ;

Schaible, HG .

NEUROSCIENCE, 2004, 127 (01) :197-206

[5] Expression of α2-adrenergic receptors in rat primary afferent neurones after peripheral nerve injury or inflammation [J].

Birder, LA ;

Perl, ER .

JOURNAL OF PHYSIOLOGY-LONDON, 1999, 515 (02) :533-542

[6] Tanezumab Reduces Osteoarthritic Hip Pain Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial [J].

Brown, Mark T. ;

Murphy, Frederick T. ;

Radin, David M. ;

Davignon, Isabelle ;

Smith, Michael D. ;

West, Christine R. .

ARTHRITIS AND RHEUMATISM, 2013, 65 (07) :1795-1803

[7] Tanezumab Reduces Osteoarthritic Knee Pain: Results of a Randomized, Double-Blind, Placebo-Controlled Phase III Trial [J].

Brown, Mark T. ;

Murphy, Frederick T. ;

Radin, David M. ;

Davignon, Isabelle ;

Smith, Michael D. ;

West, Christine R. .

JOURNAL OF PAIN, 2012, 13 (08) :790-798

[8] Somatostatin receptors on peripheral primary afferent terminals: inhibition of sensitized nociceptors [J].

Carlton, SM ;

Du, JH ;

Davidson, E ;

Zhou, ST ;

Coggeshall, RE .

PAIN, 2001, 90 (03) :233-244

[9] Intradermal recombinant human nerve growth factor induces pressure allodynia and lowered heat-pain threshold in humans [J].

Dyck, PJ ;

Peroutka, S ;

Rask, C ;

Burton, E ;

Baker, MK ;

Lehman, KA ;

Gillen, DA ;

Hokanson, JL ;

OBrien, PC .

NEUROLOGY, 1997, 48 (02) :501-505

[10] The Role of Interleukin-1β in Arthritic Pain Main Involvement in Thermal, but Not Mechanical, Hyperalgesia in Rat Antigen-Induced Arthritis [J].

Ebbinghaus, Matthias ;

Uhlig, Benjamin ;

Richter, Frank ;

von Banchet, Gisela Segond ;

Gajda, Mieczyslaw ;

Braeuer, Rolf ;

Schaible, Hans-Georg .

ARTHRITIS AND RHEUMATISM, 2012, 64 (12) :3897-3907

← 1 2 3 4 5 6 7 8 9 10 →