Bifunctionalized Amphilectane Diterpenes from the Sponge Stylissa cf. massa

被引：18

作者：

Chanthathamrongsiri, Naphatson ^{[1
]}

Yuenyongsawad, Supreeya ^{[1
]}

Wattanapiromsakul, Chatchai ^{[1
]}

Plubrukarn, Anuchit ^{[1
]}

机构：

[1] Prince Songkla Univ, Marine Nat Prod Res Unit, Dept Pharmacognosy & Pharmaceut Bot, Fac Pharmaceut Sci, Hat Yai 90112, Songkhla, Thailand

来源：

JOURNAL OF NATURAL PRODUCTS | 2012年 / 75卷 / 04期

关键词：

MARINE SPONGE; ANTIMALARIAL ACTIVITY; ADVANCED PRECURSORS; CYMBASTELA-HOOPERI; ISOTHIOCYANATE AMPHILECTENES; CYCLIC HEPTAPEPTIDES; CRIBOCHALINA SP; BIOSYNTHESIS; ISONITRILES; CARIBICA;

D O I：

10.1021/np200959j

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new amphilectane-type diterpenes, 8-isocyanato-15-formamidoamphilect-11(20)-ene (1) and 8-isothiocyanato-15-formamidoamphilect-11(20)-ene (2), along with two known derivatives, 8-isocyano-15-formarnidoamphilect-11(20)-ene (3) and 7-formamidoamphilect-11(20),15-diene (4), were isolated from the sponge Stylissa cf. massa. Diterpenes bearing two different isonitrile-related functionalities, as in 1-3, are rare. The coexistence of these compounds, all of which possess the identical carbon skeleton, in the same sponge specimen suggests interconversion among them. All the isolated compounds were tested for antimalarial activity. Compound 3 proved approximately 10 times more active than 1 and 2, indicating the importance of the isonitrile moiety to antimalarial activity versus the isocyanate and isothiocyanate groups, respectively. Compound 4, which contains only the formamide group, was inactive at the highest concentration tested.

引用

页码：789 / 792

页数：4

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