Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study

被引：35

作者：

Bhatnagar, Tarun ^{[1
]}

Chaudhuri, Sirshendu ^{[1
]}

Ponnaiah, Manickam ^{[1
]}

Yadav, Pragya D.

Sabarinathan, R. ^{[1
]}

Sahay, Rima R. ^{[13
]}

Ahmed, Faheem ^{[3
]}

Aswathy, S. ^{[2
]}

Bhardwaj, Pankaj ^{[4
]}

Bilimale, Anil ^{[5
]}

Kumar, M. Santhosh ^{[1
]}

Logaraj, M. ^{[7
]}

Narlawar, Uday ^{[6
]}

Palanivel, C. ^{[8
]}

Patel, Prakash ^{[9
]}

Rai, Sanjay K. ^{[10
]}

Saxena, Vartika ^{[11
]}

Singh, Arvind ^{[12
]}

Thangaraj, Jeromie W. V.

Agarwal, Ashwini ^{[4
]}

Alvi, Yasir ^{[3
]}

Amoghashree ^{[5
]}

Ashok, P. ^{[5
]}

Babu, Dinesh ^{[8
]}

Bahurupi, Yogesh ^{[11
]}

Bhalavi, Sangita ^{[6
]}

Behera, Priyamadhaba ^{[12
]}

Biswas, Priyanka Pandit ^{[13
]}

Charan, Jaykaran ^{[4
]}

Chauhan, Nishant Kumar

Chetak, K. B. ^{[5
]}

Dar, Lalit ^{[10
]}

Das, Ayan

Deepashree, R. ^{[5
]}

Dhar, Minakshi ^{[11
]}

Dhodapkar, Rahul ^{[8
]}

Dipu, T. S. ^{[2
]}

Dudeja, Mridu ^{[3
]}

Dudhmal, Manisha

Gadepalli, Ravisekhar ^{[4
]}

Garg, Mahendra Kumar ^{[4
]}

Gayathri, A. V. ^{[2
]}

Goel, Akhil Dhanesh ^{[4
]}

Gowdappa, H. Basavana ^{[5
]}

Guleria, Randeep ^{[10
]}

Gupta, Manoj Kumar ^{[4
]}

Islam, Farzana ^{[3
]}

Jain, Mannu

Jain, Vineet ^{[3
,9
]}

Jawahar, M. Lanord Stanley ^{[7
]}

机构：

[1] ICMR Natl Inst Epidemiol, Chennai, India

[2] Amrita Inst Med Sci, Kochi, India

[3] Hamdard Inst Med Sci & Res, New Delhi, India

[4] All India Inst Med Sci, Jodhpur, India

[5] JSS Med Coll, Mysuru, India

[6] Govt Med Coll, Nagpur, India

[7] SRM Med Coll, Chennai, India

[8] Jawaharlal Inst Postgrad Med Educ & Res, Pondicherry, India

[9] Surat Municipal Inst Med Educ & Res, Surat, India

[10] All India Inst Med Sci, New Delhi, India

[11] All India Inst Med Sci, Rishikesh, India

[12] All India Inst Med Sci, Bhubaneswar, India

[13] ICMR Natl Inst Virol, Pune, India

[14] Indian Council Med Res, New Delhi, India

来源：

INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2022年 / 122卷

关键词：

COVID-19; vaccines; BBV152/Covaxin; AZD1222/Covishield; Delta variant; Effectiveness; India; EFFICACY;

D O I：

10.1016/j.ijid.2022.07.033

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Objectives: India introduced BBV152/Covaxin and AZD1222/Covishield vaccines in January 2021. We estimated the effectiveness of these vaccines against severe COVID-19 among individuals aged >= 45 years. Methods: We did a multi-centric, hospital-based, case-control study between May and July 2021. Cases were severe COVID-19 patients, and controls were COVID-19 negative individuals from 11 hospitals. Vaccine effectiveness (VE) was estimated for complete (2 doses >= 14 days) and partial (1 dose >= 21 days) vaccination; interval between two vaccine doses and vaccination against the Delta variant. We used the random effects logistic regression model to calculate the adjusted odds ratios (aOR) with a 95% confidence interval (CI) after adjusting for relevant known confounders. Results: We enrolled 1143 cases and 2541 control patients. The VE of complete vaccination was 85% (95% CI: 79-89%) with AZD1222/Covishield and 71% (95% CI: 57-81%) with BBV152/Covaxin. The VE was highest for 6-8 weeks between two doses of AZD1222/Covishield (94%, 95% CI: 86-97%) and BBV152/Covaxin (93%, 95% CI: 34-99%). The VE estimates were similar against the Delta strain and sub-lineages. Conclusion: BBV152/Covaxin and AZD1222/Covishield were effective against severe COVID-19 among the Indian population during the period of dominance of the highly transmissible Delta variant in the second wave of the pandemic. An escalation of two-dose coverage with COVID-19 vaccines is critical to reduce severe COVID-19 and further mitigate the pandemic in the country. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

引用

页码：693 / 702

页数：10

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