Agelasines O-U, new diterpene alkaloids with a 9-N-methyladenine unit from a marine sponge Agelas sp.

被引：32

作者：

Kubota, Takaaki ^{[1
]}

Iwai, Takahiro ^{[1
]}

Takahashi-Nakaguchi, Azusa ^{[2
]}

Fromont, Jane ^{[3
]}

Gonoi, Tohru ^{[2
]}

Kobayashi, Jun'ichi ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Pharmaceut Sci, Sapporo, Hokkaido 0600812, Japan

[2] Chiba Univ, Mycol Res Ctr, Chiba 2600856, Japan

[3] Western Australian Museum, Welshpool Dc, WA 6986, Australia

来源：

TETRAHEDRON | 2012年 / 68卷 / 47期

关键词：

Marine sponge; Age las sp; Diterpene alkaloid; Bromopyrrole alkaloid; Age lasines O-U; Antimicrobial activity;

D O I：

10.1016/j.tet.2012.09.040

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New diterpene alkaloids, agelasines O-U (1-7), have been isolated from an Okinawan marine sponge Agelas sp. The gloss structures and relative stereochemistries of 1-7 were elucidated from the spectroscopic data. Agelasines O-R (1-4) were the third examples of diterpene alkaloid with a 9-N-methyladenine and a pyrrole units. Agelasine O (1) has a halimane skeleton, while agelasines P-R (2-4) have a clerodane skeleton. Agelasines S-U (5-7) were new diterpene alkaloids with a 9-N-methyladenine unit consisting of a halimane skeleton, a labdane skeleton, and a clerodane skeleton, respectively. Agelasines O-R (1-4) and T (6) showed antimicrobial activities against several bacteria and fungi. (c) 2012 Elsevier Ltd. All rights reserved.

引用

页码：9738 / 9744

页数：7

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