Protection conferred by commercial NDV live attenuated and double recombinant HVT vaccines against virulent California 2018 Newcastle disease virus (NDV) in chickens

被引:19
作者
Ferreira, Helena L. [1 ,2 ]
Reilley, Alexandra M. [3 ]
Goldenberg, Dana [1 ]
Ortiz, Ivan R. A. [3 ]
Gallardo, Rodrigo A. [4 ]
Suarez, David L. [1 ]
机构
[1] US Natl Poultry Res Ctr, Southeast Poultry Res Lab, 934 Coll Stn Rd, Athens, GA 30605 USA
[2] Univ Sao Paulo, Dept Vet Med, FZEA USP, BR-13635900 Pirassununga, SP, Brazil
[3] Merck Anim Hlth, 35500 West 91st St, Desoto, KS 66018 USA
[4] Univ Calif Davis, Sch Vet Med, Dept Populat Hlth & Reprod, Davis, CA 95616 USA
关键词
Vaccine; Newcastle disease; Poultry; Serology; Virus; Recombinant; Live attenuated; SHEDDING FOLLOWING VACCINATION; HERPESVIRUS; CHALLENGE; IMMUNIZATION; DIAGNOSIS; IMMUNITY; ONSET; ANTIBODY; STRAINS; FUSION;
D O I
10.1016/j.vaccine.2020.06.004
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Vaccines against virulent Newcastle disease virus (NDV) are widely available and can be protective, but improved vaccination protocols are needed to prevent clinical disease and reduce virus circulation. The present study evaluated the efficacy of two commercial vaccines alone or in combination: a live attenuated NDV vaccine (LV) and a recombinant herpesvirus of turkeys vector expressing the fusion protein of NDV and the virus protein 2 of infectious bursal disease virus (rHVT-ND-IBD). Chickens were vaccinated with one of four vaccination protocols: live vaccine (LV) at 1 and 11 days of age (DOA), rHVT ND-IBD and LV at 1 DOA, rHVT ND-IBD at 1 DOA boosted with an LV at 11 DOA, and rHVT ND-IBD at 1 DOA. The vaccinated birds were challenged at different time points (3 or 4 weeks of age) with the California 2018 virus. The mortality, clinical signs, mean death time (MDT), humoral response before and after vaccination, and virus shedding after challenge were evaluated. All vaccination protocols were able to prevent mortality, reduce virus shedding, and induce antibody levels before the challenge at 3 and 4 weeks-old. Overall, the antibody levels before the challenge at 4 weeks were significantly higher in all groups vaccinated with the rHVT ND-IBD when compared to levels in 3 week old birds. The combination of recombinant rHVT ND-IBD with a live vaccine at one-day-old seems to be a better combination, due to the absence of clinical signs, higher antibody levels pre and post-challenge, and reduced virus shedding at any time point after the challenge at 3 or 4 weeks of age with the California 2018 virus. Published by Elsevier Ltd.
引用
收藏
页码:5507 / 5515
页数:9
相关论文
共 41 条
[1]   Review of Newcastle disease virus with particular references to immunity and vaccination [J].
Al-Garib, SO ;
Gielkens, ALJ ;
Gruys, E ;
Koch, G .
WORLDS POULTRY SCIENCE JOURNAL, 2003, 59 (02) :185-200
[2]  
[Anonymous], TERR AN HLTH COD 201
[3]  
Armour NK, 2014, Poult Informed Prof., V134, P1
[4]   Diagnosis of virulent Newcastle disease in southern California, May 2018 [J].
Carvallo, Francisco R. ;
Moore, Janet D. ;
Nyaoke, Akinyi C. ;
Huang, Linda ;
Crossley, Beate M. ;
Uzal, Francisco A. .
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2018, 30 (04) :493-494
[5]   Characterization of Live LaSota Vaccine Strain-Induced Protection in Chickens upon Early Challenge with a Virulent Newcastle Disease Virus of Heterologous Genotype [J].
Cornax, Ingrid ;
Miller, Patti J. ;
Afonso, Claudio L. .
AVIAN DISEASES, 2012, 56 (03) :464-470
[6]   Third genome size category of avian paramyxovirus serotype 1 (Newcastle disease virus) and evolutionary implications [J].
Czegledi, Aliz ;
Ujvari, Dorina ;
Somogyi, Eszter ;
Wehmann, Eniko ;
Werner, Ortrud ;
Lomniczi, Bela .
VIRUS RESEARCH, 2006, 120 (1-2) :36-48
[7]   Removal of real-time reverse transcription polymerase chain reaction (RT-PCR) inhibitors associated with cloacal swab samples and tissues for improved diagnosis of Avian influenza virus by RT-PCR [J].
Das, Amaresh ;
Spackman, Erica ;
Pantin-Jackwood, Mary J. ;
Suarez, David L. .
JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION, 2009, 21 (06) :771-778
[8]   Updated unified phylogenetic classification system and revised nomenclature for Newcastle disease virus [J].
Dimitrov, Kiril M. ;
Abolnik, Celia ;
Afonso, Claudio L. ;
Albina, Emmanuel ;
Bahl, Justin ;
Berg, Mikael ;
Briand, Francois-Xavier ;
Brown, Ian H. ;
Choi, Kang-Seuk ;
Chvala, Ilya ;
Diel, Diego G. ;
Durr, Peter A. ;
Ferreira, Helena L. ;
Fusaro, Alice ;
Gil, Patricia ;
Goujgoulova, Gabriela, V ;
Grund, Christian ;
Hicks, Joseph T. ;
Joannis, Tony M. ;
Torchetti, Mia Kim ;
Kolosov, Sergey ;
Lambrech, Benedicte ;
Lewis, Nicola S. ;
Liu, Haijin ;
Liu, Hualei ;
McCullough, Sam ;
Miller, Patti J. ;
Monn, Isabella ;
Muller, Claude P. ;
Munir, Muhammad ;
Reischak, Dilmara ;
Sabra, Mahmoud ;
Samal, Siba K. ;
Servan de Almeida, Renata ;
Shittu, Ismaila ;
Snoeck, Chantal J. ;
Suarez, David L. ;
Van Borm, Steven ;
Wang, Zhiliang ;
Wong, Frank Y. K. .
INFECTION GENETICS AND EVOLUTION, 2019, 74
[9]   Pathogenicity and transmission of virulent Newcastle disease virus from the 2018-2019 California outbreak and related viruses in young and adult chickens [J].
Dimitrov, Kiril M. ;
Ferreira, Helena L. ;
Pantin-Jackwood, Mary J. ;
Taylor, Tonya L. ;
Goraichuk, Iryna, V ;
Crossley, Beate M. ;
Killian, Mary Lea ;
Bergeson, Nichole Hines ;
Torchetti, Mia Kim ;
Afonso, Claudio L. ;
Suarez, David L. .
VIROLOGY, 2019, 531 :203-218
[10]   Newcastle disease vaccines-A solved problem or a continuous challenge? [J].
Dimitrov, Kiril M. ;
Afonso, Claudio L. ;
Yu, Qingzhong ;
Miller, Patti J. .
VETERINARY MICROBIOLOGY, 2017, 206 :126-136