Strategies for advancing cancer nanomedicine

被引：672
作者：
Chauhan, Vikash P. [1 ,2 ,3 ]
Jain, Rakesh K. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
[3] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
来源：
NATURE MATERIALS | 2013年 / 12卷 / 11期
关键词：
HUMAN TUMOR XENOGRAFT; IN-VIVO; SOLID TUMORS; VASCULAR-PERMEABILITY; BREAST-CANCER; MICROVASCULAR PERMEABILITY; EXTRACELLULAR-MATRIX; LIPID-COMPOSITION; MOLECULAR-SIZE; DRUG-DELIVERY;
D O I：
10.1038/nmat3792
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Cancer nanomedicines approved so far minimize toxicity, but their efficacy is often limited by physiological barriers posed by the tumour microenvironment. Here, we discuss how these barriers can be overcome through innovative nanomedicine design and through creative manipulation of the tumour microenvironment.
引用
收藏
页码：958 / 962
页数：5
相关论文
共 84 条
[21]   EXAMINATION BY LASER-SCANNING CONFOCAL FLUORESCENCE IMAGING MICROSCOPY OF THE SUBCELLULAR-LOCALIZATION OF ANTHRACYCLINES IN PARENT AND MULTIDRUG-RESISTANT CELL-LINES [J].
COLEY, HM ;
AMOS, WB ;
TWENTYMAN, PR ;
WORKMAN, P .
BRITISH JOURNAL OF CANCER, 1993, 67 (06) :1316-1323
[22]   Enzyme-responsive nanoparticles for drug release and diagnostics [J].
de la Rica, Roberto ;
Aili, Daniel ;
Stevens, Molly M. .
ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (11) :967-978
[23]  
Dellian M, 2000, BRIT J CANCER, V82, P1513
[24]   Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors [J].
Diop-Frimpong, Benjamin ;
Chauhan, Vikash P. ;
Krane, Stephen ;
Boucher, Yves ;
Jain, Rakesh K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (07) :2909-2914
[25]   Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers [J].
Dreher, MR ;
Liu, WG ;
Michelich, CR ;
Dewhirst, MW ;
Yuan, F ;
Chilkoti, A .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2006, 98 (05) :335-344
[26]  
DVORAK HF, 1995, AM J PATHOL, V146, P1029
[27]  
DVORAK HF, 1986, NEW ENGL J MED, V315, P1650
[28]   Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: Concepts and applications [J].
Fleige, Emanuel ;
Quadir, Mohiuddin A. ;
Haag, Rainer .
ADVANCED DRUG DELIVERY REVIEWS, 2012, 64 (09) :866-884
[29]   Shape effects of filaments versus spherical particles in flow and drug delivery [J].
Geng, Yan ;
Dalhaimer, Paul ;
Cai, Shenshen ;
Tsai, Richard ;
Tewari, Manorama ;
Minko, Tamara ;
Discher, Dennis E. .
NATURE NANOTECHNOLOGY, 2007, 2 (04) :249-255
[30]   MICROVASCULAR PERMEABILITY OF NORMAL AND NEOPLASTIC TISSUES [J].
GERLOWSKI, LE ;
JAIN, RK .
MICROVASCULAR RESEARCH, 1986, 31 (03) :288-305
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