Strategies for advancing cancer nanomedicine

被引：686
作者：
Chauhan, Vikash P. [1 ,2 ,3 ]
Jain, Rakesh K. [1 ,2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Radiat Oncol, Edwin L Steele Lab, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA 02114 USA
[3] MIT, Koch Inst Integrat Canc Res, Cambridge, MA 02139 USA
来源：
NATURE MATERIALS | 2013年 / 12卷 / 11期
关键词：
HUMAN TUMOR XENOGRAFT; IN-VIVO; SOLID TUMORS; VASCULAR-PERMEABILITY; BREAST-CANCER; MICROVASCULAR PERMEABILITY; EXTRACELLULAR-MATRIX; LIPID-COMPOSITION; MOLECULAR-SIZE; DRUG-DELIVERY;
D O I：
10.1038/nmat3792
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Cancer nanomedicines approved so far minimize toxicity, but their efficacy is often limited by physiological barriers posed by the tumour microenvironment. Here, we discuss how these barriers can be overcome through innovative nanomedicine design and through creative manipulation of the tumour microenvironment.
引用
收藏
页码：958 / 962
页数：5
相关论文
共 84 条
[1]   Phenotypic heterogeneity of the endothelium I. Structure, function, and mechanisms [J].
Aird, William C. .
CIRCULATION RESEARCH, 2007, 100 (02) :158-173
[2]   Scaling rules for diffusive drug delivery in tumor and normal tissues [J].
Baish, James W. ;
Stylianopoulos, Triantafyllos ;
Lanning, Ryan M. ;
Kamoun, Walid S. ;
Fukumura, Dai ;
Munn, Lance L. ;
Jain, Rakesh K. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (05) :1799-1803
[3]  
Batchelor T. T., P NATL ACAD IN PRESS
[4]   Direct in vivo measurement of targeted binding in a human tumor xenograft [J].
Berk, DA ;
Yuan, F ;
Leunig, M ;
Jain, RK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (05) :1785-1790
[5]   Dynamic imaging of collagen and its modulation in tumors in vivo using second-harmonic generation [J].
Brown, E ;
McKee, T ;
diTomaso, E ;
Pluen, A ;
Seed, B ;
Boucher, Y ;
Jain, RK .
NATURE MEDICINE, 2003, 9 (06) :796-800
[6]  
Cabral H, 2011, NAT NANOTECHNOL, V6, P815, DOI [10.1038/nnano.2011.166, 10.1038/NNANO.2011.166]
[7]  
Campbell RB, 2002, CANCER RES, V62, P6831
[8]   Molecular mechanisms and clinical applications of angiogenesis [J].
Carmeliet, Peter ;
Jain, Rakesh K. .
NATURE, 2011, 473 (7347) :298-307
[9]   Role of target geometry in phagocytosis [J].
Champion, JA ;
Mitragotri, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (13) :4930-4934
[10]   Role of particle size in phagocytosis of polymeric microspheres [J].
Champion, Julie A. ;
Walker, Amanda ;
Mitragotri, Samir .
PHARMACEUTICAL RESEARCH, 2008, 25 (08) :1815-1821
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