Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

被引：72

作者：

Younge, Noelle E. . ^{[1
]}

Newgard, Christopher B. ^{[2
,3
,4
,5
]}

Cotten, C. Michael ^{[1
]}

Goldberg, Ronald N. ^{[1
]}

Muehlbauer, Michael J. ^{[2
,3
]}

Bain, James R. ^{[2
,3
,5
]}

Stevens, Robert D. ^{[2
,3
,5
]}

O'Connell, Thomas M. ^{[2
,3
,6
]}

Rawls, John F. ^{[7
]}

Seed, Patrick C. ^{[8
]}

Ashley, Patricia L. ^{[1
]}

机构：

[1] Duke Univ, Div Neonatol, Dept Pediat, Durham, NC 27710 USA

[2] Duke Univ, Duke Mol Physiol Inst, Durham, NC 27701 USA

[3] Duke Univ, Sarah W Stedman Nutr & Metab Ctr, Durham, NC 27701 USA

[4] Duke Univ, Dept Pharmacol & Canc Biol, Durham, NC 27710 USA

[5] Duke Univ, Div Endocrinol & Metab, Dept Med, Durham, NC 27710 USA

[6] Indiana Univ, Dept Otolaryngol Head & Neck Surg, Indianapolis, IN 46202 USA

[7] Duke Univ, Dept Mol Genet & Microbiol, Durham, NC 27710 USA

[8] Northwestern Univ, Dept Pediat, Chicago, IL 60611 USA

来源：

SCIENTIFIC REPORTS | 2019年 / 9卷 / 1期

关键词：

BIRTH; RESISTANCE; OUTCOMES; OBESITY; GAIN;

D O I：

10.1038/s41598-019-44547-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Growth failure during infancy is a major global problem that has adverse effects on long-term health and neurodevelopment. Preterm infants are disproportionately affected by growth failure and its effects. Herein we found that extremely preterm infants with postnatal growth failure have disrupted maturation of the intestinal microbiota, characterized by persistently low diversity, dominance of pathogenic bacteria within the Enterobacteriaceae family, and a paucity of strictly anaerobic taxa including Veillonella relative to infants with appropriate postnatal growth. Metabolomic profiling of infants with growth failure demonstrated elevated serum acylcarnitines, fatty acids, and other byproducts of lipolysis and fatty acid oxidation. Machine learning algorithms for normal maturation of the microbiota and metabolome among infants with appropriate growth revealed a pattern of delayed maturation of the microbiota and metabolome among infants with growth failure. Collectively, we identified novel microbial and metabolic features of growth failure in preterm infants and potentially modifiable targets for intervention.

引用

页数：12

共 52 条

[1] Enteral Nutrient Supply for Preterm Infants: Commentary From the European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition [J].

Agostoni, C. ;

Buonocore, G. ;

Carnielli, V. P. ;

De Curtis, M. ;

Darmaun, D. ;

Decsi, T. ;

Domellof, M. ;

Embleton, N. D. ;

Fusch, C. ;

Genzel-Boroviczeny, O. ;

Goulet, O. ;

Kalhan, S. C. ;

Kolacek, S. ;

Koletzko, B. ;

Lapillonne, A. ;

Mihatsch, W. ;

Moreno, L. ;

Neu, J. ;

Poindexter, B. ;

Puntis, J. ;

Putet, G. ;

Rigo, J. ;

Riskin, A. ;

Salle, B. ;

Sauer, P. ;

Shamir, R. ;

Szajewska, H. ;

Thureen, P. ;

Turck, D. ;

van Goudoever, J. B. ;

Ziegler, E. E. .

JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION, 2010, 50 (01) :85-91

[2] Intestinal Microbiota and Weight-Gain in Preterm Neonates [J].

Arboleya, Silvia ;

Martinez-Camblor, Pablo ;

Solis, Gonzalo ;

Suarez, Marta ;

Fernandez, Nuria ;

de los Reyes-Gavilan, Clara G. ;

Gueimonde, Miguel .

FRONTIERS IN MICROBIOLOGY, 2017, 8

[3] Mechanisms underlying the resistance to diet-induced obesity in germ-free mice [J].

Backhed, Fredrik ;

Manchester, Jill K. ;

Semenkovich, Clay F. ;

Gordon, Jeffrey I. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (03) :979-984

[4] Severe Acute Malnutrition in Childhood: Hormonal and Metabolic Status at Presentation, Response to Treatment, and Predictors of Mortality [J].

Bartz, Sarah ;

Mody, Aaloke ;

Hornik, Christoph ;

Bain, James ;

Muehlbauer, Michael ;

Kiyimba, Tonny ;

Kiboneka, Elizabeth ;

Stevens, Robert ;

Bartlett, John ;

St Peter, John V. ;

Newgard, Christopher B. ;

Freemark, Michael .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2014, 99 (06) :2128-2137

[5] Preterm Infant Linear Growth and Adiposity Gain: Trade-Offs for Later Weight Status and Intelligence Quotient [J].

Belfort, Mandy B. ;

Gillman, Matthew W. ;

Buka, Stephen L. ;

Casey, Patrick H. ;

McCormick, Marie C. .

JOURNAL OF PEDIATRICS, 2013, 163 (06) :1564-U71

[6] Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children [J].

Blanton, Laura V. ;

Charbonneau, Mark R. ;

Salih, Tarek ;

Barratt, Michael J. ;

Venkatesh, Siddarth ;

Ilkaveya, Olga ;

Subramanian, Sathish ;

Manary, Mark J. ;

Trehan, Indi ;

Jorgensen, Josh M. ;

Fan, Yue-mei ;

Henrissat, Bernard ;

Leyn, Semen A. ;

Rodionov, Dmitry A. ;

Osterman, Andrei L. ;

Maleta, KennethM. ;

Newgard, Christopher B. ;

Ashorn, Per ;

Dewey, Kathryn G. ;

Gordon, Jeffrey I. .

SCIENCE, 2016, 351 (6275)

[7] Random forests [J].

Breiman, L .

MACHINE LEARNING, 2001, 45 (01) :5-32

[8] Ultra-high-throughput microbial community analysis on the Illumina HiSeq and MiSeq platforms [J].

Caporaso, J. Gregory ;

Lauber, Christian L. ;

Walters, William A. ;

Berg-Lyons, Donna ;

Huntley, James ;

Fierer, Noah ;

Owens, Sarah M. ;

Betley, Jason ;

Fraser, Louise ;

Bauer, Markus ;

Gormley, Niall ;

Gilbert, Jack A. ;

Smith, Geoff ;

Knight, Rob .

ISME JOURNAL, 2012, 6 (08) :1621-1624

[9] Temporal and spatial variation of the human microbiota during pregnancy [J].

DiGiulio, Daniel B. ;

Callahan, Benjamin J. ;

McMurdie, Paul J. ;

Costello, Elizabeth K. ;

Lyell, Deirdre J. ;

Robaczewska, Anna ;

Sun, Christine L. ;

Goltsman, Daniela S. A. ;

Wong, Ronald J. ;

Shaw, Gary ;

Stevenson, David K. ;

Holmes, Susan P. ;

Relman, David A. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2015, 112 (35) :11060-11065

[10]

Ehrenkranz RA, 2006, PEDIATRICS, V117, P1253, DOI 10.1542/peds.2005-1368

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