JARID1/KDM5 demethylases as cancer targets?

被引:21
作者
Taylor-Papadimitriou, Joyce [1 ]
Burchell, Joy [1 ]
机构
[1] Kings Coll London, Guys Hosp, Div Canc Studies, Breast Canc Biol, London, England
关键词
Small molecular weight inhibitors; histone demethylases; H3K4; methylation; INHIBITORS; DOMAIN; CELLS;
D O I
10.1080/14728222.2017.1263616
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:5 / 7
页数:3
相关论文
共 15 条
[1]   8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors [J].
Bavetsias, Vassilios ;
Lanigan, Rachel M. ;
Ruda, Gian Filippo ;
Atrash, Butrus ;
McLaughlin, Mark G. ;
Tumber, Anthony ;
Mok, N. Yi ;
Le Bihan, Yann-Vai ;
Dempster, Sally ;
Boxall, Katherine J. ;
Jeganathan, Fiona ;
Hatch, Stephanie B. ;
Savitsky, Pavel ;
Velupillai, Srikannathasan ;
Krojer, Tobias ;
England, Katherine S. ;
Sejberg, Jimmy ;
Thai, Ching ;
Donovan, Adam ;
Pal, Akos ;
Scozzafava, Giuseppe ;
Bennett, James M. ;
Kawamura, Akane ;
Johansson, Catrine ;
Szykowska, Aleksandra ;
Gileadi, Carina ;
Burgess-Brown, Nicola A. ;
von Delft, Frank ;
Oppermann, Udo ;
Walters, Zoe ;
Shipley, Janet ;
Raynaud, Florence I. ;
Westaway, Susan M. ;
Prinjha, Rab K. ;
Fedorov, Oleg ;
Burke, Rosemary ;
Schofield, Christopher J. ;
Westwood, Isaac M. ;
Bountra, Chas ;
Mueller, Susanne ;
van Montfort, Rob L. M. ;
Brennan, Paul E. ;
Blagg, Julian .
JOURNAL OF MEDICINAL CHEMISTRY, 2016, 59 (04) :1388-1409
[2]  
Blair Lauren P, 2011, Cancers (Basel), V3, P1383, DOI 10.3390/cancers3011383
[3]   Mutations in the intellectual disability gene KDM5C reduce protein stability and demethylase activity [J].
Brookes, Emily ;
Laurent, Benoit ;
Ounap, Katrin ;
Carroll, Renee ;
Moeschler, John B. ;
Field, Michael ;
Schwartz, Charles E. ;
Gecz, Jozef ;
Shi, Yang .
HUMAN MOLECULAR GENETICS, 2015, 24 (10) :2861-2872
[4]   Characterization of a Linked Jumonji Domain of the KDM5/JARID1 Family of Histone H3 Lysine 4 Demethylases [J].
Horton, John R. ;
Engstrom, Amanda ;
Zoeller, Elizabeth L. ;
Liu, Xu ;
Shanks, John R. ;
Zhang, Xing ;
Johns, Margaret A. ;
Vertino, Paula M. ;
Fu, Haian ;
Cheng, Xiaodong .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 291 (06) :2631-2646
[5]   Identification of Jumonji AT-Rich Interactive Domain 1A Inhibitors and Their Effect on Cancer Cells [J].
Itoh, Yukihiro ;
Sawada, Hideyuki ;
Suzuki, Miki ;
Tojo, Toshifumi ;
Sasaki, Ryuzo ;
Hasegawa, Makoto ;
Mizukami, Tamio ;
Suzuki, Takayoshi .
ACS MEDICINAL CHEMISTRY LETTERS, 2015, 6 (06) :665-670
[6]  
Johansson C, 2016, NAT CHEM BIOL, V12, P539, DOI [10.1038/NCHEMBIO.2087, 10.1038/nchembio.2087]
[7]   The Histone Demethylase KDM5 Activates Gene Expression by Recognizing Chromatin Context through Its PHD Reader Motif [J].
Liu, Xingyin ;
Secombe, Julie .
CELL REPORTS, 2015, 13 (10) :2219-2231
[8]   A DNA Hypomethylation Signature Predicts Antitumor Activity of LSD1 inhibitors in SCLC [J].
Mohammad, Helai P. ;
Smitheman, Kimberly N. ;
Kamat, Chandrashekhar D. ;
Soong, David ;
Federowicz, Kelly E. ;
Van Aller, Glenn S. ;
Schneck, Jess L. ;
Carson, Jeffrey D. ;
Liu, Yan ;
Butticello, Michael ;
Bonnette, William G. ;
Gorman, Shelby A. ;
Degenhardt, Yan ;
Bai, Yuchen ;
McCabe, Michael T. ;
Pappalardi, Melissa B. ;
Kasparec, Jiri ;
Tian, Xinrong ;
McNulty, Kenneth C. ;
Rouse, Meagan ;
McDevitt, Patrick ;
Ho, Thau ;
Crouthamel, Michelle ;
Hart, Timothy K. ;
Concha, Nestor O. ;
McHugh, Charles F. ;
Miller, William H. ;
Dhanak, Dashyant ;
Tummino, Peter J. ;
Carpenter, Christopher L. ;
Johnson, Neil W. ;
Hann, Christine L. ;
Kruger, Ryan G. .
CANCER CELL, 2015, 28 (01) :57-69
[9]   RETRACTED: Histone demethylase JARID1C inactivation triggers genomic instability in sporadic renal cancer (Retracted Article. See vol 126, pg 4387, 2016) [J].
Rondinelli, Beatrice ;
Rosano, Dalia ;
Antonini, Elena ;
Frenquelli, Michela ;
Montanini, Laura ;
Huang, DaChuan ;
Segalla, Simona ;
Yoshihara, Kosuke ;
Amin, Samir B. ;
Lazarevic, Dejan ;
The, Bin Tean ;
Verhaak, Roel G. W. ;
Futreal, P. Andrew ;
Di Croce, Luciano ;
Chin, Lynda ;
Cittaro, Davide ;
Tonon, Giovanni .
JOURNAL OF CLINICAL INVESTIGATION, 2015, 125 (12) :4625-4637
[10]   Disrupted intricacy of histone H3K4 methylation in neurodevelopmental disorders [J].
Vallianatos, Christina N. ;
Iwase, Shigeki .
EPIGENOMICS, 2015, 7 (03) :503-518