Azolylchromans as a novel scaffold for anticonvulsant activity

被引：36
作者：
Emami, S [1 ]
Kebriaeezadeh, A
Zamani, MJ
Shafiee, A
机构：
[1] Mazandaran Univ Med Sci, Fac Pharm, Dept Med Chem, Sari, Iran
[2] Univ Tehran Med Sci, Fac Pharm, Pharmaceut Sci Res Ctr, Dept Pharmacol & Toxicol, Tehran, Iran
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 07期
关键词：
anticonvulsant; azole; chroman;
D O I：
10.1016/j.bmcl.2006.01.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of azolylchroman derivatives were prepared as conformationally constrained analogs of (arylalkyl)azole anticonvulsants. The anticonvulsant activities of the compounds were evaluated by determining seizure latency and protective effect against pentylenetetrazole (PTZ)-induced lethal convulsions in mice at a dose of 5 mg/kg. Among these compounds, 7-chloro-3-(1H-imidazol-1-yl)chroman-4-one and 3-(1H-1.2,4-triazol-1-yl)chroman-4-one exhibited significant action in delaying seizures as well as effective protection against PTZ-induced seizures and deaths. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1803 / 1806
页数：4
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