The use of propolis as vaccine's adjuvant

被引：41
作者：
El Ashry, El Sayed H. [1 ]
Ahmad, Tarek A. [2 ]
机构：
[1] Univ Alexandria, Fac Sci, Dept Chem, Alexandria, Egypt
[2] Bibliotheca Alexandrina, Alexandria, Egypt
来源：
VACCINE | 2012年 / 31卷 / 01期
关键词：
Propolis; Vaccines; Adjuvants; Natural products; Immunopotentiators; HERBAL MEDICINAL INGREDIENTS; CHEMICAL-COMPOSITION; IMMUNE-RESPONSE; GREEN PROPOLIS; EPIMEDIUM POLYSACCHARIDE; LYMPHOCYTE-PROLIFERATION; BIOLOGICAL-PROPERTIES; CELLULAR-RESPONSES; IN-VIVO; IMMUNIZATION;
D O I：
10.1016/j.vaccine.2012.10.095
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The success of many vaccines relies on their association with selected adjuvants in order to increase their immunogenicity and ensure long-term protection. All available adjuvants have adverse effects due to their toxicity and reactogenicity. Pre-clinical in vivo investigations can identify new natural products for further applications. Several studies have confirmed the different medicinal benefits of propolis. However the studies that addressed its use as a potent, safe, vaccine adjuvant were limited to specific countries and languages, primarily Chinese. Those studies introduced the use of different extracts and formulations of propolis as adjuvants for bacterial, viral, and parasitic vaccines. This comprehensive up-to-date review categorizes, documents, and discusses those trials in a clear chronological manner. (C) 2012 Elsevier Ltd. All rights reserved.
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收藏
页码：31 / 39
页数：9
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