Aggregation energies of some amphiphilic antidepressant drugs

The critical micelle concentrations (cmc) of the amphiphilic antidepressant drugs doxepin and butriptyline hydrochlorides in aqueous solution were determined over the temperature range 288.15-313.15 K by conductivity data and using a method based on deconvolution into Gaussians of the second derivative of the measured specific conductivity data. For fully characterization of the thermodynamics of aggregation process, the variation of the standard Gibbs energy, DeltaG(m)(0), the standard enthalpy, DeltaH(m)(0), and the standard entropy, DeltaS(m)(0), of micellization were obtained from the application of the mass action model and Phillips definition of the cmc. (C) 2002 Elsevier Science B.V. All rights reserved.