Noninvasive Raman spectroscopy in living mice for evaluation of tumor targeting with carbon nanotubes

被引：200

作者：

Zavaleta, C. ^{[1
,2
]}

de la Zerda, A. ^{[1
,2
]}

Liu, Z. ^{[3
]}

Keren, S. ^{[1
,2
]}

Cheng, Z. ^{[1
,2
]}

Schipper, M. ^{[1
,2
]}

Chen, X. ^{[1
,2
]}

Dai, H. ^{[3
]}

Gambhir, S. S. ^{[1
,2
]}

机构：

[1] Stanford Univ, Mol Imaging Program Stanford, Dept Radiol, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Bioengn, BioX Program, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

来源：

NANO LETTERS | 2008年 / 8卷 / 09期

关键词：

D O I：

10.1021/nl801362a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An optimized noninvasive Raman microscope was used to evaluate tumor targeting and localization of single walled carbon nanotubes (SWNTs) in mice. Raman images were acquired in two groups of tumor-bearing mice. The control group received plain-SWNTs, whereas the experimental group received tumor targeting RGD-SWNTs intravenously. Raman imaging commenced over the next 72 h and revealed increased accumulation of RGD-SWNTs in tumor (p < 0.05) as opposed to plain-SWNTs. These results support the development of a new preclinical Raman imager.

引用

页码：2800 / 2805

页数：6

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