Efficient asymmetric aldol reaction catalyzed by polyvinylidene chloride-supported ionic liquid/L-proline catalyst system

被引：18

作者：

Zhang, Xuan ^{[1
]}

Zhao, Wenshan ^{[2
]}

Qu, Chengke ^{[2
]}

Yang, Lili ^{[2
]}

Cui, Yuanchen ^{[1
]}

机构：

[1] Henan Univ, Minist Educ Special Funct Mat, Key Lab, Kaifeng 475004, Peoples R China

[2] Henan Univ, Coll Chem & Chem Engn, Kaifeng 475004, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2012年 / 23卷 / 6-7期

关键词：

WATER; ORGANOCATALYST; ALDEHYDES; KETONES; MEDIA; ACID;

D O I：

10.1016/j.tetasy.2012.03.023

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A series of polyvinylidene chloride (PVDC)-supported ionic liquids were derived from 4-dimethylamino-pyridine and used together with L-proline in water as efficient asymmetric organocatalysts for direct asymmetric aldol reactions between cyclohexanone and a variety of aromatic aldehydes at room temperature. These PVDC-supported ionic liquids/L-proline catalyst systems have been used as asymmetric organocatalysts to afford the corresponding aldol products with a moderate to high isolated yield of up to 99%, with diastereoselectivity of up to 6:94, and excellent enantioselectivity of up to 98%. Furthermore, they could be easily recycled and showed only a slight reduction in selectivity after seven recycles. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：468 / 473

页数：6

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