Biological activity evaluation and structure-activity relationships analysis of ferulic acid and caffeic acid derivatives for anticancer

被引：70

作者：

Li, Weixia ^{[1
]}

Li, Nianguang ^{[1
]}

Tang, Yuping ^{[1
]}

Li, Baoquan ^{[1
]}

Liu, Li ^{[1
]}

Zhang, Xu ^{[1
,2
]}

Fu, Haian ^{[3
]}

Duan, Jin-ao ^{[1
]}

机构：

[1] Nanjing Univ Chinese Med, Jiangsu Key Lab High Technol Res TCM Formulae, Nanjing 210046, Jiangsu, Peoples R China

[2] Nanjing Univ Chinese Med, Coll Basic Med, Nanjing 210046, Jiangsu, Peoples R China

[3] Emory Univ, Sch Med, Dept Pharmacol, Atlanta, GA 30322 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 19期

基金：

高等学校博士学科点专项科研基金;

关键词：

Structure-activity relationship; Derivative; Ferulic acid; Caffeic acid; Anticancer; NITRIC-OXIDE-DONOR; CHLOROGENIC ACID; TUMOR PROMOTION; CANCER CELLS; LUNG-CANCER; MOUSE SKIN; INHIBITION; NO; CARCINOGENESIS; NEOPLASIA;

D O I：

10.1016/j.bmcl.2012.08.038

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The anticancer activities of alkyl esters and NO-donors of ferulic acid (FA) and caffeic acid (CA) were assessed by a high-throughout screening (HTS) method, and the structure-activity relationships were described. CA alkyl esters had better anticancer activities than FA alkyl esters with the same alkyl sub-stituent. Mono-nitrates and phenylfuroxan nitrates were more potent than the dual nitrates. Phenylsulfonylfuroxan nitrates of FA, especially compounds 8b-8d, exhibited more potent activities in anticancer. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：6085 / 6088

页数：4

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