Galectins: new agonists of platelet activation

被引：17

作者：

Schattner, Mirta ^{[1
]}

Rabinovich, Gabriel A. ^{[2
,3
]}

机构：

[1] Natl Acad Med Buenos Aires, Lab Expt Thrombosis, Inst Expt Med IMEX CONICET, Buenos Aires, DF, Argentina

[2] Inst Biol & Expt Med IBYME CONICET, Immunopathol Lab, Buenos Aires, DF, Argentina

[3] Univ Buenos Aires, Lab Struct & Funct Glyc, Sch Exact & Nat Sci, Buenos Aires, DF, Argentina

来源：

BIOLOGICAL CHEMISTRY | 2013年 / 394卷 / 07期

关键词：

atherosclerosis; cancer; galectins; hemostasis; inflammation; platelets; VON-WILLEBRAND-FACTOR; INFLAMMATION; ALPHA(IIB)BETA(3); IDENTIFICATION; HEMOSTASIS; REGULATORS; THROMBOSIS; BINDING; PROTEIN;

D O I：

10.1515/hsz-2013-0108

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Platelet activation at sites of vascular injury leads to the formation of a hemostatic plug and is crucial for hemostasis. However, uncontrolled platelet activation may lead to the formation of occlusive thrombi. Several soluble or matricellular proteins can activate platelets. In this article, we review recent advances in knowledge of the role of galectins in platelet physiology. In soluble or immobilized form, these endogenous glycan-binding proteins trigger platelet activation through the modulation of discrete signaling pathways. We discuss the role of platelet-galectin interactions not only in hemostasis, but also in chronic inflammation, atherosclerosis and cancer.

引用

页码：857 / 863

页数：7

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