Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in the heat

被引:158
作者
Shing, Cecilia M. [1 ]
Peake, Jonathan M. [2 ,3 ]
Lim, Chin Leong [4 ,5 ]
Briskey, David [2 ,6 ]
Walsh, Neil P. [7 ]
Fortes, Matthew B. [7 ]
Ahuja, Kiran D. K. [1 ]
Vitetta, Luis [6 ]
机构
[1] Univ Tasmania, Sch Human Life Sci, Sport Performance Optimisat Res Team, Launceston, Tas 7250, Australia
[2] Univ Queensland, Sch Human Movement Studies, Brisbane, Qld, Australia
[3] Queensland Univ Technol, Sch Biomed Sci, Brisbane, Qld 4001, Australia
[4] Singapore Sports Inst, Singapore, Singapore
[5] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Physiol, Singapore 117595, Singapore
[6] Univ Queensland, Ctr Integrat, Sch Med Clin & Mol Med, Brisbane, Qld, Australia
[7] Bangor Univ, Extremes Res Grp, Bangor, Gwynedd, Wales
基金
英国医学研究理事会;
关键词
Heat stress; Gastrointestinal integrity; Gastrointestinal tract; Lipopolysaccharide; Running; Probiotics; Inflammation; INTESTINAL EPITHELIAL-CELLS; TUMOR-NECROSIS-FACTOR; STRENUOUS EXERCISE; ENDOTOXEMIA; BARRIER; STRESS; INCREASE; MODEL; PREVALENCE; ACTIVATION;
D O I
10.1007/s00421-013-2748-y
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This study aimed to investigate the effects of multi-strain probiotics supplementation on gastrointestinal permeability, systemic markers of inflammation and running performance when exercising in the heat. Ten male runners were randomized to 4 weeks of daily supplementation with a probiotics capsule (45 billion CFU of Lactobacillus, Bifidobacterium and Streptococcus strains) or placebo, separated by a washout period (double-blind, cross-over trial). After each treatment, the runners exercised to fatigue at 80 % of their ventilatory threshold at 35 A degrees C and 40 % humidity. To assess gastrointestinal permeability, runners ingested lactulose and rhamnose before exercise and post-exercise urine was collected to measure sugar concentrations. Venous blood samples were collected before, immediately after and 1 h after exercise, and core temperature was monitored during exercise. Probiotics supplementation significantly increased run time to fatigue (min:s 37:44 +/- A 2:42 versus 33:00 +/- A 2:27; P = 0.03, d = 0.54). Average core temperature during exercise was similar between trials (probiotic 38.1 +/- A 0.2 A degrees C, placebo 38.1 +/- A 0.1 A degrees C; P = 0.77, d = 0.13). Serum lipopolysaccharide concentration increased post-exercise (P < 0.001), while there was a moderate to large reduction in pre-exercise (d = 0.70) and post-exercise (d = 1.24) concentration following probiotics supplementation. Plasma concentrations of IL-6, IL-10 and IL-1ra increased after exercise (P < 0.01), but there was no significant difference between trials (P > 0.05). There was a small to moderate reduction (d = 0.35) in urine lactulose:rhamnose and a small reduction (d = 0.25) in symptoms of gastrointestinal discomfort following probiotics supplementation (both P = 0.25). Four weeks of supplementation with a multi-strain probiotic increased running time to fatigue in the heat. Further studies are required to elucidate the exact mechanisms for this performance benefit.
引用
收藏
页码:93 / 103
页数:11
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