Iron-Catalyzed Cross-Coupling Reactions of Alkyl Grignards with Aryl Sulfamates and Tosylates

被引：83
|
作者：
Agrawal, Toolika [1 ]
Cook, Silas P. [1 ]
机构：
[1] Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 01期
关键词：
SUZUKI-MIYAURA; REAGENTS; CONSTRUCTION; AMINATION; CHLORIDES; ALKENYL; SUBSTITUTION; ACTIVATION; HALIDES; ARENES;
D O I：
10.1021/ol303130j
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The iron-catalyzed cross-coupling of aryl sulfamates and tosylates has been achieved with primary and secondary alkyl Grignards. This study of iron-catalyzed cross-coupling reactions also examines the isomerization and beta-hydride elimination problems that are associated with the use of isopropyl nucleophiles. While a variety of iron sources were competent in the reaction, the use of FeF3 center dot 3H(2)O was critical to minimize nucleophile isomerization.
引用
收藏
页码：96 / 99
页数：4
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