The Significance and Therapeutic Potential of GATA3 Expression and Mutation in Breast Cancer: A Systematic Review

被引：21

作者：

Du, Feng ^{[1
]}

Yuan, Peng ^{[1
]}

Wang, Teng ^{[2
]}

Zhao, Jiuda ^{[1
]}

Zhao, Zitong ^{[3
]}

Luo, Yang ^{[1
]}

Xu, Binghe ^{[1
]}

机构：

[1] Chinese Acad Med Sci, Peking Union Med Coll, Canc Hosp, Dept Med Oncol, Beijing 100021, Peoples R China

[2] Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, Tumor Marker Res Ctr, Beijing 100191, Peoples R China

[3] Chinese Acad Med Sci, Peking Union Med Coll, Canc Inst & Hosp, State Key Lab Mol Oncol, Beijing 100191, Peoples R China

来源：

MEDICINAL RESEARCH REVIEWS | 2015年 / 35卷 / 06期

关键词：

GATA3; breast neoplasm; mutation; HELPER-CELL-DIFFERENTIATION; TRANSCRIPTION FACTOR GATA-3; ESTROGEN-RECEPTOR; MAMMARY-GLAND; DNA-BINDING; NUCLEAR-LOCALIZATION; ZINC FINGERS; STEM-CELLS; T-BET; GENE;

D O I：

10.1002/med.21362

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

GATA3 is a critical transcription factor in the development of various human systems. The notion that GATA3 expression is required for the differentiation and maintenance of normal breast tissue has been well established. Recently, GATA3 is found to actively participate in the multistep process leading breast cancer pathogenesis, including tumorigenesis, tumor differentiation, epithelial mesenchymal transition, and metastasis through regulation of various target genes. On the other hand, several studies have raised questions and highlighted the role of GATA3-low or GATA3-negative cells during the malignant development of breast cancer. In addition to gene expression, GATA3 mutations provide another dimension of complexity. As one of the most frequently mutated genes in breast cancer, GATA3 mutations may have an effect on DNA-binding ability, protein production, and transactivation activity. Recognition of the multiple function of GATA3 in breast cancer will serve to deepen our understanding of the nature of this disease and develop novel therapeutic approaches.

引用

页码：1300 / 1315

页数：16

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