Fertility preservation: current prospects and future challenges

Due to remarkable advances in cancer therapies, we have seen great improvements in survival rates of pediatric and reproductive-age male patients. Unfortunately, fertility in adult life might be severely impaired by these treatments. Gonadotoxic therapy is also used to cure a variety of non-malignant disorders. Providing young people undergoing gonadotoxic treatment with adequate fertility preservation options is a challenging area of reproductive medicine and merits broader diffusion in clinical practice. This paper, therefore, aims to review current concepts and perspectives to restore fertility from germ cells or gonadal tissue cryostored prior to gonadotoxic therapies in pre- and postpubertal patients. For patients rendered sterile after treatment, who did not benefit from fertility preservation measures before therapy, the reproductive potential of alternative sources of stem cells is also examined, although this is at the research stage.