Fulminant epstein-barr virus-associated hemophagocytic lymphohistiocytosis

被引：2

作者：

Bohne, Silvia ^{[1
]}

Kentouche, Karim ^{[2
]}

Petersen, Iver ^{[3
]}

Fritzenwanger, Michael ^{[5
]}

Pletz, Mathias W. ^{[6
]}

Lehmberg, Kai ^{[7
]}

La Rosee, Paul ^{[4
]}

Guntinas-Lichius, Orlando ^{[1
]}

机构：

[1] Univ Hosp Jena, Dept Otorhinolaryngol, D-07740 Jena, Germany

[2] Univ Hosp Jena, Dept Pediat, D-07740 Jena, Germany

[3] Univ Hosp Jena, Inst Pathol, D-07740 Jena, Germany

[4] Univ Hosp Jena, Dept Hematol & Oncol, D-07740 Jena, Germany

[5] Univ Hosp Jena, Dept Cardiol, D-07740 Jena, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Div Gastroenterol Hepatol & Infect Dis, Hamburg, Germany

[7] Univ Med Ctr Hamburg Eppendorf, Dept Pediat Hematol & Oncol, Hamburg, Germany

来源：

LARYNGOSCOPE | 2013年 / 123卷 / 02期

关键词：

Epstein-Barr virus; tonsillitis; hemophagocytic lymphohistiocytosis; SH2D1A gene; LINKED LYMPHOPROLIFERATIVE DISEASE;

D O I：

10.1002/lary.23433

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Hemophagocytic lymphohistiocytosis (HLH) is a rare, severe, and often fatal disorder. Its hereditary and sporadic form can present as a significant diagnostic challenge to the otolaryngologist. This report describes two fatal cases of adult patients with HLH initially presented as infectious mononucleosis to an otorhinolaryngologist. The clinical presentation, serological and histological features, and management are discussed.

引用

页码：362 / 365

页数：4

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