Probing gelation ability for a library of dipeptide gelators

被引：35

作者：

Awhida, Salmah ^{[1
]}

Draper, Emily R. ^{[1
]}

McDonald, Tom O. ^{[1
]}

Adams, Dave J. ^{[1
]}

机构：

[1] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2015年 / 455卷

基金：

英国工程与自然科学研究理事会;

关键词：

Peptide; Hydrogel; Low molecular weight gel; Supramolecular; Fiber; Rheology; 3-DIMENSIONAL CELL-CULTURE; MECHANICAL-PROPERTIES; SELF; HYDROGELS; NANOSTRUCTURES; ARCHITECTURE; NAPHTHALENE; DESIGN;

D O I：

10.1016/j.jcis.2015.05.032

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Functionalised dipeptides are a class of interesting and useful low molecular weight hydrogelators. Here, we report a significantly expanded library of materials, including dipeptides conjugated to carbazole, phenanthracene, anthracene, pyrene and substituted naphthalenes. We assess the effect of using two different gelation methods; a pH-switch and a solvent switch on the gelation behaviour and properties of the dipeptides. Importantly, we investigate the relationship between the structure of these dipeptides and their ability to form gels. From an analysis of the gelation ability of all these dipeptides, it is clear that those containing a phenylalanine as either of the constituent amino acids are much more likely to lead to a gelator being formed as opposed to using non-aromatic amino acids only. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：24 / 31

页数：8

共 56 条

[1] Dipeptide and Tripeptide Conjugates as Low-Molecular-Weight Hydrogelators [J].

Adams, Dave J. .

MACROMOLECULAR BIOSCIENCE, 2011, 11 (02) :160-173

[2] The delicate balance between gelation and crystallisation: structural and computational investigations [J].

Adams, Dave J. ;

Morris, Kyle ;

Chen, Lin ;

Serpell, Louise C. ;

Bacsa, John ;

Day, Graeme M. .

SOFT MATTER, 2010, 6 (17) :4144-4156

[3] Relationship between molecular structure, gelation behaviour and gel properties of Fmoc-dipeptides [J].

Adams, Dave J. ;

Mullen, Leanne M. ;

Berta, Marco ;

Chen, Lin ;

Frith, William J. .

SOFT MATTER, 2010, 6 (09) :1971-1980

[4] A new method for maintaining homogeneity during liquid-hydrogel transitions using low molecular weight hydrogelators [J].

Adams, Dave J. ;

Butler, Michael F. ;

Frith, William J. ;

Kirkland, Mark ;

Mullen, Leanne ;

Sanderson, Paul .

SOFT MATTER, 2009, 5 (09) :1856-1862

[5] Salt-induced hydrogels from functionalised-dipeptides [J].

Chen, Lin ;

McDonald, Tom O. ;

Adams, Dave J. .

RSC ADVANCES, 2013, 3 (23) :8714-8720

[6] Salt-induced hydrogelation of functionalised-dipeptides at high pH [J].

Chen, Lin ;

Pont, Guillaume ;

Morris, Kyle ;

Lotze, Gudrun ;

Squires, Adam ;

Serpell, Louise C. ;

Adams, Dave J. .

CHEMICAL COMMUNICATIONS, 2011, 47 (44) :12071-12073

[7] Tuneable mechanical properties in low molecular weight gels [J].

Chen, Lin ;

Raeburn, Jaclyn ;

Sutton, Sam ;

Spiller, David G. ;

Williams, James ;

Sharp, James S. ;

Griffiths, Peter C. ;

Heenan, Richard K. ;

King, Stephen M. ;

Paul, Alison ;

Furzeland, Steve ;

Atkins, Derek ;

Adams, Dave J. .

SOFT MATTER, 2011, 7 (20) :9721-9727

[8] Effect of Molecular Structure on the Properties of Naphthalene-Dipeptide Hydrogelators [J].

Chen, Lin ;

Revel, Steven ;

Morris, Kyle ;

Serpell, Louise C. ;

Adams, Dave J. .

LANGMUIR, 2010, 26 (16) :13466-13471

[9] Energy transfer in self-assembled dipeptide hydrogels [J].

Chen, Lin ;

Revel, Steven ;

Morris, Kyle ;

Adams, Dave J. .

CHEMICAL COMMUNICATIONS, 2010, 46 (24) :4267-4269

[10] Self-Assembly Mechanism for a Naphthalene-Dipeptide Leading to Hydrogelation [J].

Chen, Lin ;

Morris, Kyle ;

Laybourn, Andrea ;

Elias, David ;

Hicks, Matthew R. ;

Rodger, Alison ;

Serpell, Louise ;

Adams, Dave J. .

LANGMUIR, 2010, 26 (07) :5232-5242

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