Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe

被引：20

作者：

Liu, Yang ^{[1
,2
]}

Carpenter, Austin B. ^{[3
]}

Pirozzi, Christopher J. ^{[3
]}

Yuan, Hsiangkuo ^{[2
]}

Waitkus, Matthew S. ^{[3
]}

Zhou, Zhengyuan ^{[4
]}

Hansen, Landon ^{[3
]}

Seywald, Michelle ^{[2
]}

Odion, Ren ^{[2
]}

Greer, Paula K. ^{[3
]}

Hawk, Thomas ^{[4
]}

Chin, Bennett B. ^{[4
]}

Vaidyanathan, Ganesan ^{[4
]}

Zalutsky, Michael R. ^{[2
,3
,4
]}

Yan, Hai ^{[3
]}

Vo-Dinh, Tuan ^{[1
,2
,5
]}

机构：

[1] Duke Univ, Dept Chem, Durham, NC 27706 USA

[2] Duke Univ, Dept Biomed Engn, Durham, NC 27706 USA

[3] Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA

[4] Duke Univ, Med Ctr, Dept Radiol, Durham, NC 27710 USA

[5] Duke Univ, Fitzpatrick Inst Photon, Durham, NC 27708 USA

来源：

NANOTECHNOLOGY | 2019年 / 30卷 / 27期

关键词：

brain tumor detection; PET/CT; optical imaging; gold nanostar probe; DRUG-DELIVERY; CANCER; NANOPARTICLES; GLIOBLASTOMA; RADIOTHERAPY; STRATEGIES; GLIOMA; PET/CT; GRADE; IDH1;

D O I：

10.1088/1361-6528/ab0e9c

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Despite decades of efforts, non-invasive sensitive detection of small malignant brain tumors still remains challenging. Here we report a dual-modality I-241-labeled gold nanostar (I-241-GNS) probe for sensitive brain tumor imaging with positron emission tomography (PET) and subcellular tracking with two-photon photoluminescence (TPL) and electron microscopy (EM). Experiment results showed that the developed nanoprobe has potential to reach sub-millimeter intracranial brain tumor detection using PET scan, which is superior to any currently available non-invasive imaging modality. Microscopic examination using TPL and EM further confirmed that GNS nanoparticles permeated the brain tumor leaky vasculature and accumulated inside brain tumor cells following systemic administration. Selective brain tumor targeting by enhanced permeability and retention effect and ultrasensitive imaging render I-241-GNS nanoprobe promise for future brain tumor-related preclinical and translational applications.

引用

页数：12

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