Expression of Costimulatory Molecule B7-H4 in Human Malignant Tumors

被引：10
|
作者：
Zheng, Xiao [1 ]
Li, Xiao-Dong [1 ]
Wu, Chang-Ping [1 ]
Lu, Bin-Feng [2 ]
Jiang, Jing-Ting [1 ]
机构：
[1] Soochow Univ, Dept Tumor Biol Treatment, Affiliated Hosp 3, Changzhou 213003, Peoples R China
[2] Univ Pittsburgh, Dept Immunol, Sch Med, Pittsburgh, PA 15260 USA
来源：
ONKOLOGIE | 2012年 / 35卷 / 11期
关键词：
B7-H4; Costimulatory signal; Malignant tumor; Immune invasion; Molecular target; HUMAN OVARIAN-CARCINOMA; REGULATORY T-CELLS; LUNG-CANCER; B7; FAMILY; OVEREXPRESSION; SURVIVAL; IMMUNITY; PROTEIN; BREAST;
D O I：
10.1159/000343638
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
引用
收藏
页码：700 / 705
页数：6
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