Expression of Costimulatory Molecule B7-H4 in Human Malignant Tumors

被引：10
|
作者：
Zheng, Xiao [1 ]
Li, Xiao-Dong [1 ]
Wu, Chang-Ping [1 ]
Lu, Bin-Feng [2 ]
Jiang, Jing-Ting [1 ]
机构：
[1] Soochow Univ, Dept Tumor Biol Treatment, Affiliated Hosp 3, Changzhou 213003, Peoples R China
[2] Univ Pittsburgh, Dept Immunol, Sch Med, Pittsburgh, PA 15260 USA
来源：
ONKOLOGIE | 2012年 / 35卷 / 11期
关键词：
B7-H4; Costimulatory signal; Malignant tumor; Immune invasion; Molecular target; HUMAN OVARIAN-CARCINOMA; REGULATORY T-CELLS; LUNG-CANCER; B7; FAMILY; OVEREXPRESSION; SURVIVAL; IMMUNITY; PROTEIN; BREAST;
D O I：
10.1159/000343638
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Costimulatory molecule B7-H4, a member of the B7 family, negatively regulates the immune response of T cells through inhibiting their proliferation, cytokine production and cell cycle. The overexpression of B7-H4 plays an important role in initiation, progression and regression of tumors by promoting malignant transformation of epithelial cells and protecting epithelial cells from anoikis. B7-H4 expression in malignant tumors is useful for clinical diagnosis, and may provide a novel molecular target for cancer treatment.
引用
收藏
页码：700 / 705
页数：6
相关论文
共 50 条
  • [21] The expression of B7-H4 in serum and lymphoma tissues and its clinical significance
    Xie, Wenjun
    Wu, Meijuan
    Fu, Tianhong
    Li, Xiaohong
    Wang, Zhaoming
    Hu, Yongxian
    Zhu, Liyan
    Zhang, Gu
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, 2017, 10 (08): : 12361 - 12366
  • [22] B7-H4 expression in ovarian serous carcinoma: a study of 306 cases
    Liang, Li
    Jiang, Yi
    Chen, Jun-Song
    Niu, Na
    Piao, Jin
    Ning, Jing
    Zu, Youli
    Zhang, Jing
    Liu, Jinsong
    HUMAN PATHOLOGY, 2016, 57 : 1 - 6
  • [23] B7-H4 expression in human infiltrating ductal carcinoma-associated macrophages
    Liu, Lei
    Li, Dalin
    Chen, Shuang
    Zhao, Ran
    Pang, Da
    Li, Dianjun
    Fu, Zhenkun
    MOLECULAR MEDICINE REPORTS, 2016, 14 (03) : 2135 - 2142
  • [24] Expression of B7-H4 in endometrial cancer and its impact on patients' prognosis
    Gorzelnik, Katarzyna
    Wasaznik-Jedras, Anna
    Wicherek, Lukasz
    Szubert, Sebastian
    GINEKOLOGIA POLSKA, 2024, 95 (04) : 252 - 258
  • [25] Expression of the Novel Costimulatory Molecule B7-H5 in Pancreatic Cancer
    Byers, Joshua T.
    Paniccia, Alessandro
    Kaplan, Jeffrey
    Koenig, Michelle
    Kahn, Nate
    Wilson, Lora
    Chen, Lieping
    Schulick, Richard D.
    Edil, Barish H.
    Zhu, Yuwen
    ANNALS OF SURGICAL ONCOLOGY, 2015, 22 : S1574 - S1579
  • [26] Clinical relevance of expression of B7-H1 and B7-H4 in ovarian cancer
    Xu, Mei
    Zhang, Bei
    Zhang, Meng
    Liu, Yang
    Yin, Feng-Ling
    Liu, Xia
    Zhuo, Shi-Chao
    ONCOLOGY LETTERS, 2016, 11 (04) : 2815 - 2819
  • [27] Local Expression of B7-H4 by Recombinant Adenovirus Transduction in Mouse Islets Prolongs Allograft Survival
    Wang, Xiaojie
    Hao, Jianqiang
    Metzger, Daniel L.
    Mui, Alice
    Ao, Ziliang
    Verchere, C. Bruce
    Chen, Lieping
    Ou, Dawei
    Warnock, Garth L.
    TRANSPLANTATION, 2009, 87 (04) : 482 - 490
  • [28] Roles of coinhibitory molecules B7-H3 and B7-H4 in esophageal squamous cell carcinoma
    Wang, Ling
    Cao, Na-na
    Wang, Shan
    Man, Hong-wei
    Li, Peng-fei
    Shan, Bao-en
    TUMOR BIOLOGY, 2016, 37 (03) : 2961 - 2971
  • [29] In Vivo Function of Immune Inhibitory Molecule B7-H4 in Alloimmune Responses
    Yamaura, K.
    Watanabe, T.
    Boenisch, O.
    Yeung, M.
    Yang, S.
    Magee, C. N.
    Padera, R.
    Datta, S.
    Schatton, T.
    Kamimura, Y.
    Azuma, M.
    Najafian, N.
    AMERICAN JOURNAL OF TRANSPLANTATION, 2010, 10 (10) : 2355 - 2362
  • [30] B7-H4's Role "Beyond the Tumor"
    Yu, Ning
    Li, Xiaomei
    Zheng, Songguo
    Li, Xiangpei
    INFLAMMATION, 2013, 36 (04) : 941 - 947
12345