Management of Sarcoidosis: When to Treat, How to Treat and for How Long?

被引：1

作者：

Fraser, Emily ^{[1
]}

Weeratunga, Praveen ^{[1
,2
]}

Ho, Ling-Pei ^{[1
,2
]}

机构：

[1] Oxford Univ Hosp NHS Fdn Trust, Interstitial Lung Dis Serv, Oxford Sarcoidosis Clin, Oxford, England

[2] Univ Oxford, Weatherall Inst Mol Med, MRC Human Immunol Unit, Oxford, England

来源：

CURRENT PULMONOLOGY REPORTS | 2022年 / 11卷 / 04期

关键词：

Sarcoidosis; Disease mechanism; Clinical management; F-18; FDG-PET/CT; DISEASE-ACTIVITY; SOLUBLE INTERLEUKIN-2-RECEPTOR; BRONCHOALVEOLAR LAVAGE; PULMONARY SARCOIDOSIS; INFLAMMATORY ACTIVITY; T-CELLS; INFLIXIMAB; DIAGNOSIS; THERAPY;

D O I：

10.1007/s13665-022-00298-2

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Purpose of Review This review draws together recent publications, consensus statements on sarcoidosis and our 25-year collective experience in managing this disease. We focus on pulmonary sarcoidosis, highlighting recent and established concepts in disease mechanisms, the diversity of the clinical course, including possible 'subtypes' of sarcoidosis, and how to measure disease activity. We discuss the principles guiding therapeutic intervention and summarise the more recent clinical trials in sarcoidosis. Recent Findings These include recent progress in understanding the mechanisms of disease using new scientific tools, measurements of disease activity using CT and MRI scans, and the potential role of anti-fibrotic treatment for patients with progressive fibrotic sarcoidosis. Sarcoidosis is a heterogeneous disease with variable organ involvement, disease course, and response to treatment. We offer an angle on when and how to treat, and provide an overall roadmap for managing sarcoidosis.

引用

页码：151 / 159

页数：9

共 58 条

[1] PET/CT in the Diagnosis and Workup of Sarcoidosis: Focus on Atypical Manifestations [J].

Akaike, Gensuke ;

Itani, Malak ;

Shah, Hardik ;

Ahuja, Jitesh ;

Gunes, Burcak Yilmaz ;

Assaker, Richard ;

Behnia, Fatemeh .

RADIOGRAPHICS, 2018, 38 (05) :1536-1549

[2] Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement [J].

Baughman, Robert P. ;

Drent, Marjolein ;

Kavuru, Mani ;

Judson, Marc A. ;

Costabel, Ulrich ;

du Bois, Roland ;

Albera, Carlo ;

Brutsche, Martin ;

Davis, Gerald ;

Donohue, James F. ;

Mueller-Quernheim, Joachim ;

Schlenker-Herceg, Rozsa ;

Flavin, Susan ;

Lo, Kim Hung ;

Oemar, Barry ;

Barnathan, Elliot S. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (07) :795-802

[3] ERS clinical practice guidelines on treatment of sarcoidosis [J].

Baughman, Robert P. ;

Valeyre, Dominique ;

Korsten, Peter ;

Mathioudakis, Alexander G. ;

Wuyts, Wim A. ;

Wells, Athol ;

Rottoli, Paola ;

Nunes, Hiliaro ;

Lower, Elyse E. ;

Judson, Marc A. ;

Israel-Biet, Dominique ;

Grutters, Jan C. ;

Drent, Marjolein ;

Culver, Daniel A. ;

Bonella, Francesco ;

Antoniou, Katerina ;

Martone, Filippo ;

Quadder, Bernd ;

Spitzer, Ginger ;

Nagavci, Blin ;

Tonia, Thomy ;

Rigau, David ;

Ouellette, Daniel R. .

EUROPEAN RESPIRATORY JOURNAL, 2021, 58 (06)

[4] Clinical characteristics of patients in a case control study of sarcoidosis [J].

Baughman, RP ;

Teirstein, AS ;

Judson, MA ;

Rossman, MD ;

Yeager, H ;

Bresnitz, EA ;

DePalo, L ;

Hunninghake, G ;

Iannuzzi, MC ;

Johns, CJ ;

McLennan, G ;

Moller, DR ;

Newman, LS ;

Rabin, DL ;

Rose, C ;

Rybicki, B ;

Weinberger, SE ;

Terrin, ML ;

Knatterud, GL ;

Cherniak, R .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2001, 164 (10) :1885-1889

[5]

Baughman RP., 2021, SARCOIDOSIS VASC DIF, V38

[6] Diagnosis and Treatment of Pulmonary Sarcoidosis A Review [J].

Belperio, John A. ;

Shaikh, Faisal ;

Abtin, Fereidoun G. ;

Fishbein, Michael C. ;

Weigt, S. Samuel ;

Saggar, Rajan ;

Lynch, Joseph P., III .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2022, 327 (09) :856-867

[7] CTAS: a CT score to quantify disease activity in pulmonary sarcoidosis [J].

Benamore, Rachel ;

Kendrick, Yvonne R. ;

Repapi, Emmanouela ;

Helm, Emma ;

Cole, Suzanne L. ;

Taylor, Stephen ;

Ho, Ling-Pei .

THORAX, 2016, 71 (12) :1161-+

[8] Cardiac Sarcoidosis [J].

Birnie, David H. ;

Nery, Pablo B. ;

Ha, Andrew C. ;

Beanlands, Rob S. B. .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2016, 68 (04) :411-421

[9] HRS Expert Consensus Statement on the Diagnosis and Management of Arrhythmias Associated With Cardiac Sarcoidosis [J].

Birnie, David H. ;

Sauer, William H. ;

Bogun, Frank ;

Cooper, Joshua M. ;

Culver, Daniel A. ;

Duvernoy, Claire S. ;

Judson, Marc A. ;

Kron, Jordana ;

Mehta, Davendra ;

Nielsen, Jens Cosedis ;

Patel, Amit R. ;

Ohe, Tohru ;

Raatikainen, Pekka ;

Soejima, Kyoko .

HEART RHYTHM, 2014, 11 (07) :1304-1323

[10] Abnormalities in iNKT cells are associated with impaired ability of monocytes to produce IL-10 and suppress T-cell proliferation in sarcoidosis [J].

Crawshaw, Anjali ;

Kendrick, Yvonne R. ;

McMichael, Andrew J. ;

Ho, Ling-Pei .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2014, 44 (07) :2165-2174

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