Can needle-free administration of vaccines become the norm in global immunization?

被引:120
作者
Levine, Myron M. [1 ]
机构
[1] Univ Maryland, Sch Med, Ctr Vaccine Dev, Baltimore, MD 21201 USA
关键词
D O I
10.1038/nm0103-99
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
If vaccines could be administered without needles and syringes ('sharps'), immunization practice would become safer, more accepted and more suitable for mass use. The author explores the status of technologies that could achieve this aim and the barriers that must be overcome for their implementation.
引用
收藏
页码:99 / 103
页数:5
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共 41 条
  • [1] Ågren LC, 1999, J IMMUNOL, V162, P2432
  • [2] American Academy of Family Physicians American Academy of Pediatrics Advisory Committee on Immunization Practices Public Health Service, 2000, MMWR-MORBID MORTAL W, V49, P631
  • [3] AYLWARD B, 1995, B WORLD HEALTH ORGAN, V73, P531
  • [4] The efficacy of live attenuated, cold-adapted, trivalent, intranasal influenzavirus vaccine in children
    Belshe, RB
    Mendelman, PM
    Treanor, J
    King, J
    Gruber, WC
    Piedra, P
    Bernstein, DI
    Hayden, FG
    Kotloff, K
    Zangwill, K
    Iacuzio, D
    Wolff, M
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (20) : 1405 - 1412
  • [5] AN OUTBREAK OF HEPATITIS-B ASSOCIATED WITH JET INJECTIONS IN A WEIGHT-REDUCTION CLINIC
    CANTER, J
    MACKEY, K
    GOOD, LS
    ROBERTO, RR
    CHIN, J
    BOND, WW
    ALTER, MJ
    HORAN, JM
    [J]. ARCHIVES OF INTERNAL MEDICINE, 1990, 150 (09) : 1923 - 1927
  • [6] Centers for Disease Control and Prevention (CDC), 2000, MMWR Morb Mortal Wkly Rep, V49, P631
  • [7] Albendazole treatment of children with ascariasis enhances the vibriocidal antibody response to the live attenuated oral cholera vaccine CVD 103-HgR
    Cooper, PJ
    Chico, ME
    Losonsky, G
    Sandoval, C
    Espinel, I
    Sridhara, R
    Aguilar, M
    Guevara, A
    Guderian, RH
    Levine, MM
    Griffin, GE
    Nutman, TB
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2000, 182 (04) : 1199 - 1206
  • [8] Response to different measles vaccine strains given by aerosol and subcutaneous routes to schoolchildren: a randomised trial
    Dilraj, A
    Cutts, FT
    de Castro, JF
    Wheeler, JG
    Brown, D
    Roth, C
    Coovadia, HM
    Bennett, JV
    [J]. LANCET, 2000, 355 (9206) : 798 - 803
  • [9] MUTANTS OF ESCHERICHIA-COLI HEAT-LABILE TOXIN LACKING ADP-RIBOSYLTRANSFERASE ACTIVITY ACT AS NONTOXIC, MUCOSAL ADJUVANTS
    DOUCE, G
    TURCOTTE, C
    CROPLEY, I
    ROBERTS, M
    PIZZA, M
    DOMENGHINI, M
    RAPPUOLI, R
    DOUGAN, G
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (05) : 1644 - 1648
  • [10] Clinical immunogenicity and tolerance studies of liquid vaccines delivered by jet-injector and a new single-use cartridge (Imule(R)): Comparison with standard syringe injection
    duChatelet, IP
    Lang, J
    Schlumberger, M
    Vidor, E
    Soula, G
    Genet, A
    Standaert, SM
    Saliou, P
    Gueye, A
    Julien, H
    Lafaix, C
    Lemardeley, P
    Monnereau, A
    Spiegel, A
    Soke, M
    Varichon, JP
    [J]. VACCINE, 1997, 15 (04) : 449 - 458