The L-type calcium channel in the heart: the beat goes on

被引：210
|
作者：
Bodi, I [1 ]
Mikala, G [1 ]
Koch, SE [1 ]
Akhter, SA [1 ]
Schwartz, A [1 ]
机构：
[1] Univ Cincinnati, Coll Med, Dept Surg, Inst Mol Pharmacol & Biophys, Cincinnati, OH 45267 USA
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期
关键词：
D O I：
10.1172/JCI27167
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.
引用
收藏
页码：3306 / 3317
页数：12
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