The L-type calcium channel in the heart: the beat goes on

被引：210

作者：

Bodi, I ^{[1
]}

Mikala, G ^{[1
]}

Koch, SE ^{[1
]}

Akhter, SA ^{[1
]}

Schwartz, A ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Surg, Inst Mol Pharmacol & Biophys, Cincinnati, OH 45267 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期

关键词：

D O I：

10.1172/JCI27167

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

引用

页码：3306 / 3317

页数：12

共 50 条

[1] Expression of the L-type calcium channel in human heart failure
Joachim Hersel
Simon Jung
Paul Mohacsi
Roger Hullin
Basic Research in Cardiology, 2002, 97 (Suppl 1) : I4 - I10
[2] Denitration of L-type calcium channel
Kang, Minho
Akbarali, Hamid I.
FEBS LETTERS, 2008, 582 (20) : 3033 - 3036
[3] L-type calcium channel modulation
Dolphin, AC
ION CHANNEL REGULATION, 1999, 33 : 153 - 177
[4] Differential localization of L-type calcium channel β subunit isoforms in the heart
Foell, JD
Balijepalli, RC
Robia, SL
Yunker, AMR
Cohen, RM
McEnery, MW
Walker, JW
Kamp, TJ
CIRCULATION, 2001, 104 (17) : 252 - 252
[5] L-type Calcium Channel C-terminus Suppresses L-type Calcium Channel Transcription in Cardiomyocytes
Schroder, Elizabeth A.
Byse, Miranda J.
Satin, Jonathan
CIRCULATION, 2008, 118 (18) : S398 - S398
[6] Killer protein and L-type calcium channels: using a novel L-type calcium channel inhibitor to characterize L-type calcium channel structure, function, and voltage dependence
Williams, Alexis
Smith, Thomas
PROTEIN SCIENCE, 2017, 26 : 192 - 193
[7] L-Type Calcium Channel Antagonists and Suppression of Expression of Plasminogen Receptors Is the Missing Link the L-Type Calcium Channel?
Bkaily, Ghassan
Jacques, Danielle
CIRCULATION RESEARCH, 2009, 105 (02) : 112 - 113
[8] Modeling L-type Calcium Channel with Phenylalkylamines
Cheng, Ricky C. K.
Tikhonov, Denis B.
Zhorov, Boris S.
BIOPHYSICAL JOURNAL, 2009, 96 (03) : 183A - 183A
[9] REGULATION OF THE L-TYPE CALCIUM-CHANNEL
HOFMANN, F
NASTAINCZYK, W
ROHRKASTEN, A
SCHNEIDER, T
SIEBER, M
TRENDS IN PHARMACOLOGICAL SCIENCES, 1987, 8 (10) : 393 - 398
[10] Modeling L-type Calcium Channel with Dihydropyridines
Tikhonov, Denis B.
Zhorov, Boris S.
BIOPHYSICAL JOURNAL, 2009, 96 (03) : 182A - 183A

← 1 2 3 4 5 →