The L-type calcium channel in the heart: the beat goes on

被引：210

作者：

Bodi, I ^{[1
]}

Mikala, G ^{[1
]}

Koch, SE ^{[1
]}

Akhter, SA ^{[1
]}

Schwartz, A ^{[1
]}

机构：

[1] Univ Cincinnati, Coll Med, Dept Surg, Inst Mol Pharmacol & Biophys, Cincinnati, OH 45267 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2005年 / 115卷 / 12期

关键词：

D O I：

10.1172/JCI27167

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sydney Ringer would be overwhelmed today by the implications of his simple experiment performed over 120 years ago showing that the heart would not beat in the absence of Ca2+. Fascination with the role of Ca2+ has proliferated into all aspects of our understanding of normal cardiac function and the progression of heart disease, including induction of cardiac hypertrophy, heart failure, and sudden death. This review examines the role of Ca2+ and the L-type voltage-dependent Ca2+ channels in cardiac disease.

引用

页码：3306 / 3317

页数：12

共 126 条

[1] Structure-functional diversity of human L-type Ca2+ channel:: Perspectives for new pharmacological targets
Abernethy, DR
Soldatov, NM
[J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2002, 300 (03) : 724 - 728
[2] Calmodulin kinase signaling in heart: an intriguing candidate target for therapy of myocardial dysfunction and arrhythmias
Anderson, ME
[J]. PHARMACOLOGY & THERAPEUTICS, 2005, 106 (01) : 39 - 55
[3] Calmodulin kinase and L-type calcium channels: A recipe for arrhythmias?
Anderson, ME
[J]. TRENDS IN CARDIOVASCULAR MEDICINE, 2004, 14 (04) : 152 - 161
[4] Auxiliary subunits: essential components of the voltage-gated calcium channel complex
Arikkath, J
Campbell, KP
[J]. CURRENT OPINION IN NEUROBIOLOGY, 2003, 13 (03) : 298 - 307
[5] Ball SL, 2002, INVEST OPHTH VIS SCI, V43, P1595
[6] Benitah J. P., 2002, BASIC RES CARDIOL S1, V97, P111
[7] INTRACELLULAR CALCIUM HANDLING IN ISOLATED VENTRICULAR MYOCYTES FROM PATIENTS WITH TERMINAL HEART-FAILURE
BEUCKELMANN, DJ
NABAUER, M
ERDMANN, E
[J]. CIRCULATION, 1992, 85 (03) : 1046 - 1055
[8] MECHANISM OF RELEASE OF CALCIUM FROM SARCOPLASMIC-RETICULUM OF GUINEA-PIG CARDIAC-CELLS
BEUCKELMANN, DJ
WIER, WG
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1988, 405 : 233 - 255
[9] Perspective - Voltage sensor movements
Bezanilla, F
[J]. JOURNAL OF GENERAL PHYSIOLOGY, 2002, 120 (04) : 465 - 473
[10] The I-II loop of the Ca2+ channel α1 subunit contains an endoplasmic reticulum retention signal antagonized by the β subunit
Bichet, D
Cornet, V
Geib, S
Carlier, E
Volsen, S
Hoshi, T
Mori, Y
De Waard, M
[J]. NEURON, 2000, 25 (01) : 177 - 190

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