Novel structures of Zn(II) biometal cation with the biologically active substituted acetic acid and nitrogen donor ligands: Synthesis, spectral, phosphate diester catalytic hydrolysis and antimicrobial studies

The complexes [Zn(methoxyacetate)(2)1,10-phenanthroline] 1 and [Zn-2(phenylacetate) 4 (quinoline) 2] 2, were prepared and characterized by IR-spectroscopy, UV-Visible spectroscopy, H-1 and C-13 NMR spectroscopy, single crystal X-ray diffraction. BNPP hydrolysis of the complexes and their parent nitrogen ligands were scanned, the results indicated that the hydrolysis rates of BNPP were 4.5 x 10(4) and 6.2 x 10(5) for (1) and (2), respectively. In addition, anti-bacterial activities were scanned to investigate the effect of complexation on their activity against Gram-positive (S. epidermidis, S. aureus, E. faecalis, M. luteus and B. Subtilis) and Gram-negative (K. pneumonia, E. coli, P. Mirabilis and P. Aeruginosa) bacteria using agar well-diffusion method. Complex 1 showed high activity against G(-) and G(+) bacteria except against E. faecalis and P. Aeruginosa. Complex 2 did not show any activity against G(-) or G(+) bacteria.