Syntheses based on norfluorocurarine. 5. NMR spectra of monomeric norfluorocurarine derivatives

被引：1

作者：

Levkovich, M. G. ^{[1
]}

Yuldashev, P. Kh. ^{[1
]}

Mirzaeva, M. M. ^{[1
]}

Tashkhodzhaev, B. ^{[1
]}

机构：

[1] Uzbek Acad Sci, S Yu Yunusov Inst Chem Plant Subst, Tashkent 700135, Uzbekistan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2012年 / 48卷 / 03期

关键词：

indole alkaloids; fluorocurarine; norfluorocurarine; NMR spectroscopy; VINERVININE; VINCANIDINE; ALKALOIDS;

D O I：

10.1007/s10600-012-0269-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

NMR spectra of norfluorocurarine and seven of its derivatives were studied. The NMR spectral parameters were related to stereochemical features using molecular modeling by the semi-empirical AM1 approximation. The resulting steric characteristics of the molecules in solution agreed well with x-ray structure data. The only difference from the x-ray structure data was the ability of several substituents to rotate.

引用

页码：440 / 446

页数：7

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