A new antifungal and cytotoxic C-methylated flavone glycoside from Picea neoveitchii

被引：28

作者：

Chen, Wei-Quan ^{[1
,2
]}

Song, Zhi-Jun ^{[1
,2
]}

Xu, Han-Hong ^{[1
,2
]}

机构：

[1] S China Agr Univ, State Key Lab Conservat & Utilizat Subtrop Agrobi, Wushan Guangzhou 510642, Peoples R China

[2] S China Agr Univ, Key Lab Nat Pesticide & Chem Biol, Minist Educ, Wushan Guangzhou 510642, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2012年 / 22卷 / 18期

基金：

中国博士后科学基金;

关键词：

Picea neoveitchii; Pinaceae; C-Methylated flavone glycoside; Antifungal activity; Cytotoxicity; JEZOENSIS VAR. HONDOENSIS; PINUS-DENSIFLORA; CUTICLE; EPOXYSERRATANES; TRITERPENOIDS; MORRISONICOLA; GLUCOSIDES; HEARTWOOD; BARK;

D O I：

10.1016/j.bmcl.2012.07.089

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new C-methylated flavone glycoside, 5,7-dihydroxy-3-methoxy-6-C-methylflavone 8,4'-di-O-beta-D-glucopyranoside (1), was isolated from the twigs and leaves of Picea neoveitchii Mast, together with eight known compounds, 5,7,8,4'-tetrahydroxy-3-methoxy-6-methylflavone 8-O-beta-D-glucopyranoside (2) kaempferol 3,4'-di-O-beta-D-glucopyranoside (3), apigenin 7-O-beta-D-glucopyranoside (4), tiliroside (5), massonianoside B (6), umbeliferone 7-O-beta-D-glucopyranoside (7), dihydroconiferin (8) and gleditschiaside A (9). Their structures were elucidated on the basis of analyses of spectroscopic data. Compound 1 showed moderate antifungal activity against tested plant pathogens (Pyricularia grisea (Cooke) Sacc., Sclerotium rocfsii Sacc. and Alternaria mali Roberts), however, compounds 2 and 5 had obvious inhibitory effect against S. rocfsii and A. mali, respectively. Compounds 1, 2, 3 and 9 also exhibited potent cytotoxicity against Spodoptera litura Fabricius cells. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：5819 / 5822

页数：4

共 31 条

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