pH-responsive carrier system based on carboxylic acid modified mesoporous silica and polyelectrolyte for drug delivery

被引：430
作者：
Yang, Q
Wang, SH
Fan, PW
Wang, LF
Di, Y
Lin, KF
Xiao, FS [1 ]
机构：
[1] Jilin Univ, Dept Chem, Changchun 130012, Peoples R China
[2] Jilin Univ, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China
来源：
CHEMISTRY OF MATERIALS | 2005年 / 17卷 / 24期
关键词：
D O I：
10.1021/cm051198v
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
An efficient pH-responsive carrier system has been constructed by oppositely charged ionic interaction between carboxylic acid modified SBA-15 silica rods and polyelectrolyte. Active molecules such as vancomycin can be stored and released from the pore voids of SBA-15 by changing pH values at will. The amount of vancomycin stored in the pores of sample based on carboxylic acid modified SBA-15 rods and poly(dimethyldiallylammonium chloride) is up to 36.4 wt % at pH 6.8. When the pH is at mild acidity, vancomycin is steadily released from the pores of SBA-15. Both nitrogen adsorption-desorption isothems and X-ray diffraction patterns show that this system possesses stable mesostructure, which will be considered an interesting alternative to a polymeric delivery system.
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收藏
页码：5999 / 6003
页数：5
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