Mad1 promotes chromosome congression by anchoring a kinesin motor to the kinetochore
被引:48
作者:
Akera, Takashi
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Akera, Takashi
[1
,2
]
Goto, Yuhei
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Goto, Yuhei
[1
,2
]
Sato, Masamitsu
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Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Sato, Masamitsu
[2
]
Yamamoto, Masayuki
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Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Yamamoto, Masayuki
[2
]
Watanabe, Yoshinori
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Watanabe, Yoshinori
[1
,2
]
机构:
[1] Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
[2] Univ Tokyo, Grad Program Biophys & Biochem, Grad Sch Sci, Tokyo 1130032, Japan
For proper partitioning of genomes in mitosis, all chromosomes must be aligned at the spindle equator before the onset of anaphase. The spindle assembly checkpoint (SAC) monitors this process, generating a 'wait anaphase' signal at unattached kinetochores of misaligned chromosomes. However, the link between SAC activation and chromosome alignment is poorly understood. Here we show that Mad1, a core SAC component, plays a hitherto concealed role in chromosome alignment. Protein-protein interaction screening revealed that fission yeast Mad1 binds the plus-end-directed kinesin-5 motor protein Cut7 (Eg5 homologue), which is generally thought to promote spindle bipolarity. We demonstrate that Mad1 recruits Cut7 to kinetochores of misaligned chromosomes and promotes chromosome gliding towards the spindle equator. Similarly, human Mad1 recruits another kinetochore motor CENP-E, revealing that Mad1 is the conserved dual-function protein acting in SAC activation and chromosome gliding. Our results suggest that the mitotic checkpoint has co-evolved with a mechanism to drive chromosome congression.
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Kawashima, Shigehiro A.
Yamagishi, Yuya
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Sci, Grad Program Biophys & Biochem, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Yamagishi, Yuya
Honda, Takashi
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Honda, Takashi
Ishiguro, Kei-ichiro
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Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Ishiguro, Kei-ichiro
Watanabe, Yoshinori
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h-index: 0
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Sci, Grad Program Biophys & Biochem, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Kawashima, Shigehiro A.
Yamagishi, Yuya
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h-index: 0
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Sci, Grad Program Biophys & Biochem, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Yamagishi, Yuya
Honda, Takashi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Honda, Takashi
Ishiguro, Kei-ichiro
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h-index: 0
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Ishiguro, Kei-ichiro
Watanabe, Yoshinori
论文数: 0引用数: 0
h-index: 0
机构:
Univ Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Sci, Grad Program Biophys & Biochem, Tokyo 1130032, Japan
Univ Tokyo, Grad Sch Agr & Life Sci, Tokyo 1130032, JapanUniv Tokyo, Inst Mol & Cellular Biosci, Lab Chromosome Dynam, Tokyo 1130032, Japan