Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome

被引:414
|
作者
Ussar, Siegfried [1 ,2 ,3 ]
Griffin, Nicholas W. [4 ,5 ]
Bezy, Olivier [1 ,2 ]
Fujisaka, Shiho [1 ,2 ]
Vienberg, Sara [1 ,2 ]
Softic, Samir [1 ,2 ]
Deng, Luxue [6 ]
Bry, Lynn [6 ]
Gordon, Jeffrey I. [4 ,5 ]
Kahn, C. Ronald [1 ,2 ]
机构
[1] Joslin Diabet Ctr, Boston, MA 02215 USA
[2] Harvard Univ, Sch Med, Boston, MA 02215 USA
[3] Helmholtz Ctr Munich, Helmholtz Diabet Ctr, Inst Diabet & Obes, D-85764 Munich, Germany
[4] Washington Univ, Sch Med, Ctr Genome Sci & Syst Biol, St Louis, MO 63108 USA
[5] Washington Univ, Sch Med, Ctr Gut Microbiome & Nutr Res, St Louis, MO 63108 USA
[6] Harvard Univ, Sch Med, Brigham & Womens Hosp, Ctr Clin & Translat Metagen,Dept Pathol, Boston, MA 02111 USA
关键词
INTESTINAL MICROBIOTA; INSULIN-RESISTANCE; WIDE ASSOCIATION; SYSTEMS BIOLOGY; DISEASE; INDIVIDUALS; METAGENOME; LOCI;
D O I
10.1016/j.cmet.2015.07.007
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Obesity, diabetes, and metabolic syndrome result from complex interactions between genetic and environmental factors, including the gut microbiota. To dissect these interactions, we utilized three commonly used inbred strains of mice-obesity/diabetes-prone C57Bl/6J mice, obesity/diabetes-resistant 129S1/SvImJ from Jackson Laboratory, and obesity-prone but diabetes-resistant 129S6/SvEvTac from Taconic-plus three derivative lines generated by breeding these strains in a new, common environment. Analysis of metabolic parameters and gut microbiota in all strains and their environmentally normalized derivatives revealed strong interactions between microbiota, diet, breeding site, and metabolic phenotype. Strain-dependent and strain-independent correlations were found between specific microbiota and phenotypes, some of which could be transferred to germ-free recipient animals by fecal transplantation. Environmental reprogramming of microbiota resulted in 129S6/SvEvTac becoming obesity resistant. Thus, development of obesity/metabolic syndrome is the result of interactions between gut microbiota, host genetics, and diet. In permissive genetic backgrounds, environmental reprograming of microbiota can ameliorate development of metabolic syndrome.
引用
收藏
页码:516 / 530
页数:15
相关论文
共 50 条
  • [1] Interactions between Gut Microbiota, Host Genetics and Diet Modulate the Predisposition to Obesity and Metabolic Syndrome (vol 22, pg 516, 2015)
    Ussar, Siegfried
    Griffin, Nicholas W.
    Bezy, Olivier
    Fujisaka, Shiho
    Vienberg, Sara
    Softic, Samir
    Deng, Luxue
    Bry, Lynn
    Gordon, Jeffrey I.
    Kahn, C. Ronald
    CELL METABOLISM, 2016, 23 (03) : 564 - 566
  • [2] Host genetics and diet composition interact to modulate gut microbiota and predisposition to metabolic syndrome in spontaneously hypertensive stroke-prone rats
    Singh, Arashdeep
    Zapata, Rizaldy C.
    Pezeshki, Adel
    Workentine, Matthew L.
    Chelikani, Prasanth K.
    FASEB JOURNAL, 2019, 33 (06): : 6748 - 6766
  • [4] Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
    Chenhong Zhang
    Menghui Zhang
    Shengyue Wang
    Ruijun Han
    Youfang Cao
    Weiying Hua
    Yuejian Mao
    Xiaojun Zhang
    Xiaoyan Pang
    Chaochun Wei
    Guoping Zhao
    Yan Chen
    Liping Zhao
    The ISME Journal, 2010, 4 : 232 - 241
  • [5] Interactions between gut microbiota, host genetics and diet relevant to development of metabolic syndromes in mice
    Zhang, Chenhong
    Zhang, Menghui
    Wang, Shengyue
    Han, Ruijun
    Cao, Youfang
    Hua, Weiying
    Mao, Yuejian
    Zhang, Xiaojun
    Pang, Xiaoyan
    Wei, Chaochun
    Zhao, Guoping
    Chen, Yan
    Zhao, Liping
    ISME JOURNAL, 2010, 4 (02): : 232 - 241
  • [6] Gut microbiota and host genetics modulate the effect of diverse diet patterns on metabolic health
    Huda, M. Nazmul
    Salvador, Anna C. C.
    Barrington, William T. T.
    Gacasan, C. Anthony
    D'Souza, Edeline M.
    Ramirez, Laura Deus
    Threadgill, David W. W.
    Bennett, Brian J. J.
    FRONTIERS IN NUTRITION, 2022, 9
  • [7] Interactions between host genetics and gut microbiome in diabetes and metabolic syndrome
    Ussar, Siegfried
    Fujisaka, Shiho
    Kahn, C. Ronald
    MOLECULAR METABOLISM, 2016, 5 (09): : 795 - 803
  • [8] The effect of heritability and host genetics on the gut microbiota and metabolic syndrome
    Lim, Mi Young
    You, Hyun Ju
    Yoon, Hyo Shin
    Kwon, Bomi
    Lee, Jae Yoon
    Lee, Sunghee
    Song, Yun-Mi
    Lee, Kayoung
    Sung, Joohon
    Ko, GwangPyo
    GUT, 2017, 66 (06) : 1031 - 1038
  • [9] Diet, Gut Microbiota, and Obesity: Links with Host Genetics and Epigenetics and Potential Applications
    Cuevas-Sierra, Amanda
    Ramos-Lopez, Omar
    Riezu-Boj, Jose I.
    Milagro, Fermin I.
    Alfredo Martinez, J.
    ADVANCES IN NUTRITION, 2019, 10 : S17 - S30
  • [10] Altered Gut Microbiota: A Link Between Diet and the Metabolic Syndrome
    Velasquez, Manuel T.
    METABOLIC SYNDROME AND RELATED DISORDERS, 2018, 16 (07) : 321 - 328