Therapeutic Potential of Ursolic Acid to Manage Neurodegenerative and Psychiatric Diseases

被引:51
|
作者
Ramos-Hryb, Ana B. [1 ]
Pazini, Francis L. [1 ]
Kaster, Manuella P. [1 ]
Rodrigues, Ana Lucia S. [1 ]
机构
[1] Univ Fed Santa Catarina, Dept Biochem, Ctr Biol Sci, BR-88040900 Florianopolis, SC, Brazil
关键词
EARLY BRAIN-INJURY; TRIPLE REUPTAKE INHIBITORS; INDUCED COGNITIVE DEFICITS; ORIGANUM-MAJORANA L; OLEANOLIC ACID; OXIDATIVE STRESS; MITOCHONDRIAL-FUNCTION; MONOAMINE-OXIDASE; NEXT-GENERATION; OFFICINALIS L;
D O I
10.1007/s40263-017-0474-4
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Ursolic acid is a pentacyclic triterpenoid found in several plants. Despite its initial use as a pharmacologically inactive emulsifier in pharmaceutical, cosmetic and food industries, several biological activities have been reported for this compound so far, including anti-tumoural, anti-diabetic, cardioprotective and hepatoprotective properties. The biological effects of ursolic acid have been evaluated in vitro, in different cell types and against several toxic insults (i.e. 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, amyloid-beta peptides, kainic acid and others); in animal models of brain-related disorders (Alzheimer disease, Parkinson disease, depression, traumatic brain injury) and ageing; and in clinical studies with cancer patients and for muscle atrophy. Most of the protective effects of ursolic acid are related to its ability to prevent oxidative damage and excessive inflammation, common mechanisms associated with multiple brain disorders. Additionally, ursolic acid is capable of modulating the monoaminergic system, an effect that might be involved in its ability to prevent mood and cognitive dysfunctions associated with neurodegenerative and psychiatric conditions. This review presents and discusses the available evidence of the possible beneficial effects of ursolic acid for the management of neurodegenerative and psychiatric disorders. We also discuss the chemical features, major sources and potential limitations of the use of ursolic acid as a pharmacological treatment for brain-related diseases.
引用
收藏
页码:1029 / 1041
页数:13
相关论文
共 50 条
  • [31] The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases
    Lam, Jenny
    Coleman, Nichole
    Garing, April Lourdes A.
    Wulff, Heike
    EXPERT OPINION ON THERAPEUTIC TARGETS, 2013, 17 (10) : 1203 - 1220
  • [32] Therapeutic Potential of α-Crystallins in Retinal Neurodegenerative Diseases
    Phadte, Ashutosh S.
    Sluzala, Zachary B.
    Fort, Patrice E.
    ANTIOXIDANTS, 2021, 10 (07)
  • [33] Ferroptosis: A potential therapeutic target for neurodegenerative diseases
    Vitalakumar, D.
    Sharma, Ankita
    Flora, Swaran J. S.
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2021, 35 (08)
  • [34] Necroptosis in neurodegenerative diseases: a potential therapeutic target
    Shuo Zhang
    Mi-bo Tang
    Hai-yang Luo
    Chang-he Shi
    Yu-ming Xu
    Cell Death & Disease, 2017, 8 : e2905 - e2905
  • [35] Therapeutic potential of triheptanoin in metabolic and neurodegenerative diseases
    Wehbe, Zeinab
    Tucci, Sara
    JOURNAL OF INHERITED METABOLIC DISEASE, 2020, 43 (03) : 385 - 391
  • [36] Ursolic acid (UA): A metabolite with promising therapeutic potential
    Kashyap, Dharambir
    Tuli, Hardeep Singh
    Sharma, Anil K.
    LIFE SCIENCES, 2016, 146 : 201 - 213
  • [37] Therapeutic potential of olfactory ensheathing cells in neurodegenerative diseases
    Chiu, Shao-Chih
    Hung, Huey-Shan
    Lin, Shinn-Zong
    Chiang, Esheral
    Liu, Demeral David
    JOURNAL OF MOLECULAR MEDICINE-JMM, 2009, 87 (12): : 1179 - 1189
  • [38] The therapeutic potential of probucol and probucol analogues in neurodegenerative diseases
    Sharif, Arazu
    Mamo, John
    Lam, Virginie
    Al-Salami, Hani
    Mooranian, Armin
    Watts, Gerald F.
    Clarnette, Roger
    Luna, Giuseppe
    Takechi, Ryu
    TRANSLATIONAL NEURODEGENERATION, 2024, 13 (01)
  • [39] The multifaceted functions of β-arrestins and their therapeutic potential in neurodegenerative diseases
    Kee, Teresa R.
    Khan, Sophia A.
    Neidhart, Maya B.
    Masters, Brianna M.
    Zhao, Victoria K.
    Kim, Yenna K.
    McGill Percy, Kyle C.
    Woo, Jung-A A.
    EXPERIMENTAL AND MOLECULAR MEDICINE, 2024, 56 (01): : 129 - 141
  • [40] Neural stem cells: therapeutic potential for neurodegenerative diseases
    Gincberg, Galit
    Arien-Zakay, Hadar
    Lazarovici, Philip
    Lelkes, Peter I.
    BRITISH MEDICAL BULLETIN, 2012, 104 (01) : 7 - 19