Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

被引：134
|
作者：
Kirschning, Andreas [1 ]
Hahn, Frank [1 ]
机构：
[1] Leibniz Univ Hannover, Inst Organ Chem & Biomol Wirkstoffzentrum BMWZ, D-30167 Hannover, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 17期
关键词：
metabolic engineering; mutasynthesis; natural products; semisynthesis; total synthesis; ANTITUMOR AGENT ANSAMITOCIN; COMBINATORIAL BIOSYNTHESIS; GLYCOPEPTIDE ANTIBIOTICS; SUBSTRATE-SPECIFICITY; GENE-CLUSTER; MUTASYNTHESIS; DERIVATIVES; HSP90; SEMISYNTHESIS; CRYPTOPHYCINS;
D O I：
10.1002/anie.201107386
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：4012 / 4022
页数：11
相关论文
共 50 条
  • [1] Total Synthesis of Complex Natural Products: Combination of Chemical Synthesis and Biosynthesis Strategies
    Li, Xiaojun
    Zhang, Wanbin
    Gao, Shuanhu
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 38 (09) : 2185 - 2198
  • [2] New enzymes for chemical synthesis exploring natural product biosynthesis
    Tao, Junhua
    Burkart, Michael D.
    CHIMICA OGGI-CHEMISTRY TODAY, 2007, 25 (02) : 3 - 7
  • [3] Biosynthesis and Chemical Synthesis of Presilphiperfolanol Natural Products
    Hong, Allen Y.
    Stoltz, Brian M.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2014, 53 (21) : 5248 - 5260
  • [4] Dyotropic rearrangements in natural product total synthesis and biosynthesis
    Hugelshofer, Cedric L.
    Magauer, Thomas
    NATURAL PRODUCT REPORTS, 2017, 34 (03) : 228 - 234
  • [5] Nitropyrrole natural products: isolation, biosynthesis and total synthesis
    Ding, Xiao-Bo
    Brimble, Margaret A.
    Furkert, Daniel P.
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2016, 14 (24) : 5390 - 5401
  • [6] Structure, Chemical Synthesis, and Biosynthesis of Prodiginine Natural Products
    Hu, Dennis X.
    Withall, David M.
    Challis, Gregory L.
    Thomson, Regan J.
    CHEMICAL REVIEWS, 2016, 116 (14) : 7818 - 7853
  • [7] Natural products in synthesis and biosynthesis
    Dickschat, Jeroen S.
    BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY, 2013, 9 : 1897 - 1898
  • [8] Biosynthesis and Total Synthesis Studies on the Jadomycin Family of Natural Products
    Sharif, Ehesan U.
    O'Doherty, George A.
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2012, 2012 (11) : 2095 - 2108
  • [9] The isoprostanes, a new class of natural products: Synthesis and biosynthesis
    Rokach, J
    Khanapure, SP
    Hwang, SW
    Adiyaman, M
    Schio, L
    Fitzgerald, GA
    SYNTHESIS-STUTTGART, 1998, : 569 - 580
  • [10] The Isoprostanes, A New Class of Natural Products: Synthesis and Biosynthesis
    Rokach, J.
    Khanapure, S. P.
    Hwang, S.-W.
    Adiyaman, M.
    Synthesis,
12345