A case report and focused literature review of d-penicillamine and severe neutropenia: A serious toxicity from a seldom-used drug

被引：9

作者：

Pitman, Stuart K. ^{[1
,2
]}

Tony Huynh ^{[1
]}

Bjarnason, Thorarinn A. ^{[3
]}

An, Josiah ^{[3
]}

Malkhasyan, Karen A. ^{[3
,4
]}

机构：

[1] Univ Iowa Healthcare, Dept Pharmaceut Care, Iowa City, IA USA

[2] Univ Iowa, Coll Pharm, Iowa City, IA 52242 USA

[3] Univ Iowa Healthcare, Iowa City, IA USA

[4] Yale New Haven Med Ctr, New Haven, CT USA

来源：

CLINICAL CASE REPORTS | 2019年 / 7卷 / 05期

关键词：

neutropenia; penicillamine; Wilson's disease; FATAL APLASTIC-ANEMIA; RHEUMATOID-ARTHRITIS; WILSONS-DISEASE; INDUCED AGRANULOCYTOSIS; ADVERSE-REACTIONS; THERAPY; DIAGNOSIS; AZATHIOPRINE;

D O I：

10.1002/ccr3.2125

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Key Clinical Message Prescribing d-penicillamine for Wilson's disease must be accompanied by vigilant monitoring, including a complete blood cell count with differential. For most, this should occur once or twice weekly during the first month of therapy and during periods of dose escalation, then every two weeks for six additional months, then monthly.

引用

页码：990 / 994

页数：5

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