Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

被引：17
作者：
Goswami, Lalit N. [1 ]
Khan, Aslam A. [1 ]
Jalisatgi, Satish S. [1 ]
Hawthorne, M. Frederick [1 ]
机构：
[1] Univ Missouri, Sch Med, Int Inst Nano & Mol Med, Columbia, MO 65211 USA
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 43期
关键词：
MRI; DESIGN;
D O I：
10.1039/c4cc02126f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (F-19) magnetic resonance spectroscopy (F-19-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl) phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo- B-12(2-)-core via suitable linkers. The F-19-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.
引用
收藏
页码：5793 / 5795
页数：3
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