Synthesis and in vitro assessment of a bifunctional closomer probe for fluorine (19F) magnetic resonance and optical bimodal cellular imaging

被引：18

作者：

Goswami, Lalit N. ^{[1
]}

Khan, Aslam A. ^{[1
]}

Jalisatgi, Satish S. ^{[1
]}

Hawthorne, M. Frederick ^{[1
]}

机构：

[1] Univ Missouri, Sch Med, Int Inst Nano & Mol Med, Columbia, MO 65211 USA

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 43期

关键词：

MRI; DESIGN;

D O I：

10.1039/c4cc02126f

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The design, synthesis and in vitro assessment of a bifunctional imaging probe for dual fluorine (F-19) magnetic resonance spectroscopy (F-19-MRS) and fluorescence detection is reported. Eleven copies of 3,5-bis(trifluoromethyl) phenyl and a single copy of a sulforhodamine-B were covalently attached to a closo- B-12(2-)-core via suitable linkers. The F-19-MRS and fluorescence imaging shows that, this novel bimodal imaging probe was readily taken up by the cells in vitro after co-incubation.

引用

页码：5793 / 5795

页数：3

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