Molecular characterization of a MSRV-like sequence identified by RDA from monozygotic twin pairs discordant for schizophrenia

被引：55

作者：

Deb-Rinker, P

Klempan, TA

O'Reilly, RL

Torrey, EF

Singh, SM ^{[1
]}

机构：

[1] Univ Western Ontario, Dept Zool, Mol Genet Unit, London, ON N6A 5B7, Canada

[2] Univ Western Ontario, Div Med Genet, London, ON N6A 5B7, Canada

[3] Univ Western Ontario, Dept Psychiat, London, ON N6A 5B7, Canada

[4] NIMH, Stanley Fdn Res Programs, Neurosci Ctr St Elizabeths, Washington, DC 20032 USA

[5] London Hlth Sci Ctr, Child Hlth Res Inst, Mol Med Genet Program, London, ON N6A 2V5, Canada

来源：

GENOMICS | 1999年 / 61卷 / 02期

关键词：

D O I：

10.1006/geno.1999.5946

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Retroviral-related amplicons were used in modified RDA to identify four sequences from affected members of three pairs of monozygotic twins discordant for schizophrenia. One sequence (schizophrenia associated retrovirus, SZRV-1, GenBank Accession No. AF135487) is characterized here. It is similar to two known sequences of retroviral origin: multiple sclerosis-associated retrovirus, MSRV (GenBank Accession No. AF009668), and ERV-9 (GenBank Accession No. S77575). It is present in multiple copies in the human genome and has been localized to six different chromosomal sites. A zooblot shows that this multicopy sequence is predominant in the primate lineage and present in rhesus monkeys and humans. SZRV-1 is expressed as a 9-kb RNA band in the placenta. This could offer support to the hypothesis that retroviral sequences transposing during fetal growth may alter neurodevelopmental genes and cause diseases, although its direct involvement in the causation of schizophrenia remains to be established. (C) 1999 Academic Press.

引用

页码：133 / 144

页数：12

共 41 条

[1] INSERTIONAL MUTAGENESIS BY TRANSPOSABLE ELEMENTS IN THE MAMMALIAN GENOME [J].