The role of radiation therapy in the management of primary thymic epithelial neoplasms

被引：0

作者：

Johnstone, Candice ^{[1
]}

Simone, Charles B., II ^{[2
]}

机构：

[1] Med Coll Wisconsin, Dept Radiat Oncol, Milwaukee, WI 53211 USA

[2] New York Proton Ctr, Dept Radiat Oncol, New York, NY 10035 USA

来源：

JOURNAL OF CANCER METASTASIS AND TREATMENT | 2022年 / 8卷

关键词：

Thymoma; thymic carcinoma; post-operative radiation therapy; POSTOPERATIVE RADIOTHERAPY; III THYMOMA; STAGE-II; RESECTED THYMOMA; ADJUVANT PROTON; MALIGNANCIES; GUIDELINES; CARCINOMA; SURVIVAL; TUMORS;

D O I：

10.20517/2394-4722.2021.211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Therapeutic radiation plays an important role in the management of thymoma and thymic carcinoma. These two tumor types differ substantially in their aggressiveness and prognosis. The most pressing issue in radiotherapy is which thymoma and thymic carcinoma patients need radiation. Given that these are rare cancers, few randomized trials have been published. Controversy remains regarding which patients benefit from adjuvant radiation therapy. Existing literature spans patients treated over nearly 50 years, during which time radiation therapy has evolved from rudimentary 2-dimensional based planning to conformal 3-dimensional planning to yet more conformal dose painting techniques such as intensity-modulated radiation therapy and proton therapy. If the effect of radiation is small and the natural history of a disease long, as is the case for stage I favorable histology thymoma, then differences in techniques and toxicities may have as much of an impact as whether radiation was given or not.

引用

页数：14

共 53 条

[1] Managing oligoprogressive malignant pleural mesothelioma with stereotactic body radiation therapy [J].

Barsky, Andrew R. ;

Yegya-Raman, Nikhil ;

Katz, Sharyn I. ;

Simone, Charles B., II ;

Cengel, Keith A. .

LUNG CANCER, 2021, 157 :163-164

[2] RADIORYTHMIC: Phase III, Opened, Randomized Study of Postoperative Radiotherapy Versus Surveillance in Stage IIb/III of Masaoka Koga Thymoma after Complete Surgical Resection [J].

Basse, C. ;

Botticella, A. ;

Molina, T. J. ;

Falcoz, P. E. ;

Oulkhouir, Y. ;

Kerjouan, M. ;

Pichon, E. ;

Westeel, V ;

Thiberville, L. ;

Quantin, X. ;

Clement-Duchene, C. ;

Khalifa, J. ;

Le Tinier, F. ;

Ginoux, M. ;

Thillays, F. ;

Mordant, P. ;

Besse, B. ;

Thomas, P. A. ;

Le Pechoux, C. ;

Girard, Nicolas .

CLINICAL LUNG CANCER, 2021, 22 (05) :469-472

[3] Multidisciplinary Tumor Board Decision Making for Postoperative Radiotherapy in Thymic Epithelial Tumors: Insights from the RYTHMIC Prospective Cohort [J].

Basse, Clemence ;

Thureau, Sebastien ;

Bota, Suzanna ;

Dansin, Eric ;

Thomas, Pascal-Alexandre ;

Pichon, Eric ;

Lena, Herve ;

Massabeau, Carole ;

Clement-Duchene, Christelle ;

Massard, Gilbert ;

Westeel, Virginie ;

Quantin, Xavier ;

Oulkhouir, Youssef ;

Danhier, Serge ;

Lerouge, Delphine ;

Tanguy, Ronan ;

Thillays, Francois ;

Le Pechoux, Cecile ;

Dubray, Bernard ;

Thiberville, Luc ;

Besse, Benjamin ;

Girard, Nicolas .

JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) :1715-1722

[4] Postoperative Radiotherapy in Locally Invasive Malignancies of the Thymus: Patterns of Care and Survival [J].

Boothe, Dustin ;

Orton, Andrew ;

Thorpe, Cameron ;

Kokeny, Kristine ;

Hitchcock, Ying J. .

JOURNAL OF THORACIC ONCOLOGY, 2016, 11 (12) :2218-2226

[5] The role of postoperative radiotherapy for thymomas: a multicentric retrospective evaluation from three Italian centers and review of the literature [J].

Bruni, Alessio ;

Stefani, Alessandro ;

Perna, Marco ;

Borghetti, Paolo ;

Levra, Niccolo Giaj ;

D'Angelo, Elisa ;

D'Onofrio, Alessandra ;

Rubino, Laura ;

Frassinelli, Luca ;

Salvestrini, Viola ;

Mariotti, Matteo ;

Alongi, Filippo ;

Gonfiotti, Alessandro ;

Livi, Lorenzo ;

Scotti, Vieri .

JOURNAL OF THORACIC DISEASE, 2020, 12 (12) :7518-7530

[6] Adaptive Radiation Therapy for Intact Thymoma: An Illustrative Report [J].

CHEVLI, N. E. I. L. ;

BLAND, R. O. S. S. E. ;

FARACH, A. N. D. R. E. W. M. ;

PINO, R. A. M. I. R. O. ;

MATHEWS, T. H. O. M. A. S. ;

OKOYE, E. K. E. N. E., I ;

BLACKMON, S. H. A. N. D. A. ;

BUTLER, E. B. R. I. A. N. ;

TEH, B. I. N. S. .

ANTICANCER RESEARCH, 2021, 41 (05) :2467-2471

[7] Clinical management of patients with thymic epithelial tumors: the recommendations endorsed by the Italian Association of Medical Oncology (AIOM) [J].

Conforti, F. ;

Marino, M. ;

Vitolo, V. ;

Spaggiari, L. ;

Mantegazza, R. ;

Zucali, P. ;

Ruffini, E. ;

Di Tommaso, L. ;

Pelosi, G. ;

Barberis, M. ;

Petrini, I. ;

Palmieri, G. ;

Pasello, G. ;

Galli, G. ;

Berardi, R. ;

Garassino, M. ;

Filosso, P. ;

Alloisio, M. ;

Scorsetti, M. ;

Orecchia, R. ;

Pala, L. ;

Abatedaga, L. ;

Cinieri, S. ;

De Pas, T. .

ESMO OPEN, 2021, 6 (04)

[8] The Management of Thymoma: A Systematic Review and Practice Guideline [J].

Falkson, Conrad B. ;

Bezjak, Andrea ;

Darling, Gail ;

Gregg, Richard ;

Malthaner, Richard ;

Maziak, Donna E. ;

Yu, Edward ;

Smith, Christopher A. ;

McNair, Sheila ;

Ung, Yee C. ;

Evans, William K. .

JOURNAL OF THORACIC ONCOLOGY, 2009, 4 (07) :911-919

[9] POSTOPERATIVE RADIOTHERAPY AFTER SURGICAL RESECTION OF THYMOMA: DIFFERING ROLES IN LOCALIZED AND REGIONAL DISEASE [J].

Forquer, Jeffrey A. ;

Rong, Nan ;

Fakiris, Achilles J. ;

Loehrer, Patrick J., Sr. ;

Johnstone, Peter A. S. .

INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 2010, 76 (02) :440-445

[10] Thymic epithelial tumours: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-upaEuro [J].

Girard, N. ;

Ruffini, E. ;

Marx, A. ;

Faivre-Finn, C. ;

Peters, S. .

ANNALS OF ONCOLOGY, 2015, 26 :V40-V55

← 1 2 3 4 5 6 →