Pilot-Scale Production of Dimethyl 1,4-Cubanedicarboxylate

被引：49

作者：

Falkiner, Michael J. ^{[1
]}

Littler, Stuart W. ^{[1
]}

McRae, Kenneth J. ^{[1
]}

Savage, G. Paul ^{[1
]}

Tsanaktsidis, John ^{[1
]}

机构：

[1] CSIRO Mat Sci & Engn, Ian Wark Lab, Clayton, Vic 3168, Australia

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2013年 / 17卷 / 12期

关键词：

PH-SENSITIVE HYDROGELS; VAPOR-PRESSURES; ORAL DELIVERY; SOLID CUBANE; IN-VITRO; SUBLIMATION; WAY-100635; PYROLYSIS; STABILITY; CHEMISTRY;

D O I：

10.1021/op400181g

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A scalable process for the preparation of high purity dimethyl 1,4-cubanedicarboxylate (3) is reported. The work described herein builds on previous synthetic work from this and other laboratories, to provide a reliable process that can be used to prepare multigram quantities of 3 in a partially telescoped, 8 step process, with minimal purification of intermediates.

引用

页码：1503 / 1509

页数：7

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