A link between inflammation and thrombosis in atherosclerotic cardiovascular diseases: Clinical and therapeutic implications

被引:77
作者
Oikonomou, Evangelos [1 ]
Leopoulou, Marianna [1 ]
Theofilis, Panagiotis [1 ]
Antonopoulos, Alexios S. [1 ]
Siasos, Gerasimos [1 ]
Latsios, George [1 ]
Mystakidi, Vasiliki Chara [1 ]
Antoniades, Charalambos [2 ]
Tousoulis, Dimitris [1 ]
机构
[1] Natl & Kapodistrian Univ Athens, Hippokration Hosp, Dept Cardiol 1, Med Sch, Athens, Greece
[2] Univ Oxford, Radcliffe Dept Med, Div Cardiovasc Med, Oxford, England
关键词
Atherosclerosis; Cardiovascular disease; Cytokines; Inflammation; Thrombosis; Platelets; C-REACTIVE PROTEIN; CORONARY-ARTERY-DISEASE; VON-WILLEBRAND-FACTOR; ST-SEGMENT ELEVATION; NEUTROPHIL EXTRACELLULAR TRAPS; ACUTE MYOCARDIAL-INFARCTION; MEAN PLATELET VOLUME; SOLUBLE CD40 LIGAND; ENDOTHELIAL-CELLS; TISSUE FACTOR;
D O I
10.1016/j.atherosclerosis.2020.07.027
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The association between thrombosis and acute coronary syndromes is well established. Inflammation and activation of innate and adaptive immunity are another important factor implicated in atherosclerosis. However, the exact interactions between thrombosis and inflammation in atherosclerosis are less well understood. Accumulating data suggest a firm interaction between these two key pathophysiologic processes. Pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin-6 and interleukin-1, have been implicated in the thrombotic cascade following plaque rupture and myocardial infarction. Furthermore, cell adhesion molecules accelerate not only atheromatosis but also thrombosis formation while activated platelets are able to trigger leukocyte adhesion and accumulation. Additionally, tissue factor, thrombin, and activated coagulation factors induce the release of pro-inflammatory cytokines such as prostaglandin and C reactive protein, which may further induce von Willebrand factor secretion. Treatments targeting immune activation (i.e. interleukin-1 inhibitors, colchicine, statins, etc.) may also beneficially modulate platelet activation while common antithrombotic therapies appear to attenuate the inflammatory process. Taken together in the context of cardiovascular diseases, thrombosis and inflammation should be studied and managed as a common entity under the concept of thrombo-inflammation.
引用
收藏
页码:16 / 26
页数:11
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